射频电磁场和磁性纳米粒子诱导的细胞旁观者效应
Cell bystander effect induced by radiofrequency electromagnetic fields and magnetic nanoparticles
摘要：
电离辐射直接照射的辐射效应是辐射防护、临床诊断和肿瘤治疗等领域的研究热点。一定剂量的直接照射诱导细胞死亡，但类似的效应也可以发生在未直接暴露于IR的细胞中，这种机制称为旁观者效应。非红外线（射频波）可以诱导死亡的细胞装载MNP在集中肿瘤治疗称为磁热疗。间接机制也能够诱导未负载的MNP细胞的死亡。使用体外细胞模型，我们发现，共定位的MNP在溶酶体和非增加的温度诱导旁观者效应下non-IR。我们的研究结果提供了一个景观，其中旁观者效应是一个更普遍的机制，到目前为止，只观察到和临床上使用的放射治疗领域。
英文摘要：
Induced effects by direct exposure to ionizing radiation (IR) are a central issue in many fields like radiation protection, clinic diagnosis and oncological therapies. Direct irradiation at certain doses induce cell death, but similar effects can also occur in cells no directly exposed to IR, a mechanism known as bystander effect. Non-IR (radiofrequency waves) can induce the death of cells loaded with MNPs in a focused oncological therapy known as magnetic hyperthermia. Indirect mechanisms are also able to induce the death of unloaded MNPs cells. Using in vitro cell models, we found that colocalization of the MNPs at the lysosomes and the non-increase of the temperature induces bystander effect under non-IR. Our results provide a landscape in which bystander effects are a more general mechanism, up to now only observed and clinically used in the field of radiotherapy.
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