钴结合罗丹明-123探测聚甲基丙烯酸及其共聚物复合物的结构和动力学
Structure and Dynamics of Poly(methacrylic acid) and Its Interpolymer Complex Probed by Covalently Bound Rhodamine-123
摘要：
用单分子荧光法研究了聚甲基丙烯酸结合罗丹明123（PMAAR 123）及其与聚乙烯吡咯烷酮（PVP）的共聚物复合物的动力学和结构特征。PMAA-R123在不同pH下的时间分辨荧光各向异性衰减表现出荧光团所经历的两种不同环境的相关各向异性衰减行为特征，并以一种较短和另一种较长的寿命组分衰减。的各向异性衰减保持正常的双指数行为在中性pH值下。荧光相关光谱研究表明，所附的荧光团在碱性条件下发生水解，从而导致从聚合物骨架的荧光团的释放。在添加互补聚合物PVP时观察到PMAA的流体动力学半径的收缩，这归因于形成紧凑的溶解的纳米颗粒状聚集体。加入NaCl后，颗粒尺寸进一步减小。详细的结果表明，这些配合物具有潜在的生理条件下作为药物传递系统。
英文摘要：
The dynamics and structural characteristics of polymethacrylic acid bound rhodamine-123 (PMAAR123) and its interpolymer complex with poly(vinylpyrrolidone) were investigated using single molecular fluorescence studies. The time resolved fluorescence anisotropy decay of PMAA-R123 at different pH exhibits an associated anisotropy decay behavior characteristic of two different environments experienced by the fluorophore and decays with one shorter and another longer lifetime components. The anisotropy decay retains normal bi-exponential behavior under neutral pH. Fluorescence correlation spectroscopic investigation reveals that the attached fluorophore undergoes hydrolysis under basic condition which results in the release of the fluorophore from the polymer backbone. Shrinkage in the hydrodynamic radius of PMAA is observed on addition of the complementary polymer PVP which is attributed to the formation compact solubilized nanoparticle like aggregates. The size of particle further decreases on the addition of NaCl. The detailed results show that these complexes have potential for use as drug-delivery system under physiological conditions.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
