利用基因组双链断裂降低微生物繁殖力
Exploitation of the genomic double-strand breaks to reduce the reproductive power of microorganisms
摘要：
它展示了如何利用原核细胞基因组中频繁发生的双链断裂，以降低其高效繁殖能力。该分析检查每个断裂的自由端的物理状态，并考虑这种状态如何干扰外部物理装置，目的是破坏修复过程。我们表明这种相互作用的生物学后果，我们给出了一个近似的拓扑和动力学的影响，所涉及的基因组材料上出现的评价。总体结果表明修复的动力学显著降低。
英文摘要：
It is shown how to take advantage of the frequent occurrence of double-strand breaks in the genome of prokaryotic cells, in order to reduce their high efficient reproductive capability. The analysis examines the physical status of the free ends of each break and considers how this status can interfere with an external physical apparatus, with the aim of undermining the repair processes. We indicate the biological consequences of this interaction and we give an approximate evaluation of the topological and dynamical effects that arise on the genomic material involved. The overall result suggests a significant reduction of the dynamics of the repair.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
