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arXiv 1505.04493stat.ME
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弱条件下大协方差阵对依赖结构的比较及其在基因聚类中的应用

Comparing large covariance matrices under weak conditions on the dependence structure and its application to gene clustering

Jinyuan Chang, Wen Zhou, Wen-Xin Zhou, Lan Wang

摘要:

比较大的协方差阵在现代基因组学中具有重要的应用,在现代基因组学中,科学家通常对理解关系(例如,依赖性或共同调节)在不同的生物状态之间变化。当协方差阵的维数远大于样本量时,我们提出了一个快速的计算过程来检验两个大的协方差阵是否相等。新方法的一个显著特点是对未知的协方差阵不作任何结构性假设。因此,该测试对于基因组学中经常出现的各种复杂的依赖结构是稳健的。我们证明了所提出的方法在弱矩条件下是渐进有效的。作为一个有趣的应用程序,我们得到了一个新的基因聚类算法,该算法具有相同的好属性,避免了高维基因组数据的限制性结构假设。使用哮喘基因表达数据集,我们说明了新的测试如何帮助比较疾病组和对照组之间不同基因集/途径的基因的协方差阵,以及基因聚类算法如何提供关于两组之间基因聚类模式不同的新见解。所提出的方法已在R-包HDtest中实现,并可在CRAN上使用。

英文摘要:

Comparing large covariance matrices has important applications in modern genomics, where scientists are often interested in understanding whether relationships (e.g., dependencies or co-regulations) among a large number of genes vary between different biological states. We propose a computationally fast procedure for testing the equality of two large covariance matrices when the dimensions of the covariance matrices are much larger than the sample sizes. A distinguishing feature of the new procedure is that it imposes no structural assumptions on the unknown covariance matrices. Hence the test is robust with respect to various complex dependence structures that frequently arise in genomics. We prove that the proposed procedure is asymptotically valid under weak moment conditions. As an interesting application, we derive a new gene clustering algorithm which shares the same nice property of avoiding restrictive structural assumptions for high-dimensional genomics data. Using an asthma gene expression dataset, we illustrate how the new test helps compare the covariance matrices of the genes across different gene sets/pathways between the disease group and the control group, and how the gene clustering algorithm provides new insights on the way gene clustering patterns differ between the two groups. The proposed methods have been implemented in an R-package HDtest and is available on CRAN.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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