新生儿脐带血和母血中单个人红细胞的三维refractive index断层图像和变形性
3-D refractive index tomograms and deformability of individual human red blood cells from cord blood of newborn infants and maternal blood
摘要：
来自新生儿脐带血的红细胞（RBC）对胎儿和婴儿发育具有独特的功能。为了系统地研究新生儿单个脐带红细胞的生物物理特性，采用光学全息显微断层扫描对新生儿脐带血的红细胞和来自母亲或非妊娠妇女的成人红细胞进行了比较研究。光学测量的3-D折射率分布，和动态膜波动的单个红细胞，使检索的形态，生化和机械性能的脐带，母体和成人红细胞在单个细胞水平。脐带红细胞的体积和表面积明显大于非妊娠妇女的红细胞，并且脐带红细胞比成人的红细胞具有更扁平的形状。此外，新生儿脐带红细胞中的Hb含量显著高于正常对照组。脐血红细胞血红蛋白浓度高于非妊娠妇女或母体红细胞，但在成人生理范围内。有趣的是，脐带红细胞的动态膜波动幅度与非妊娠妇女和母体红细胞的波动幅度相当，表明脐带红细胞的变形性与成人健康红细胞的变形性相似。
英文摘要：
Red blood cells (RBCs) from the cord blood of newborn infants have distinctive functions for fetal and infant development. To systematically investigate the biophysical characteristics of individual cord RBCs in newborn infants, a comparative study was performed of RBCs from cord blood of newborn infants, and of adult RBCs from mothers or non-pregnant women, employing optical holographic micro-tomography. Optical measurements of 3-D refractive index distributions, and of dynamic membrane fluctuations of individual RBCs, enabled retrieval of the morphological, biochemical, and mechanical properties of cord, maternal, and adult RBCs at the individual cell level. The volume and surface area of the cord RBCs were significant larger than those of RBCs from non-pregnant women, and cord RBCs have more flattened shapes than RBCs in adults. In addition, the Hb content in the cord RBCs of newborns was significantly greater. The Hb concentration in cord RBCs was higher than for non-pregnant women or maternal RBCs, but they were within the physiological range of adults. Interestingly, the amplitude of dynamic membrane fluctuations in cord RBCs were comparable to those in non-pregnant women and maternal RBCs, suggesting that the deformability of cord RBCs is similar to that of healthy RBCs in adults.
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