绝对配体辨别的案例：免疫T细胞的信息处理和决策建模
The case for absolute ligand discrimination : modeling information processing and decision by immune T cells
摘要：
一些细胞必须根据周围配体的质量做出决定，几乎不考虑它们的数量，我们称之为“绝对歧视”。绝对辨别的一个例子是免疫T细胞对非我的识别。我们展示了如何绝对歧视的问题可以解决的过程称为“自适应排序”。我们回顾了自适应排序的几种实现，以及它的一般属性，如拮抗作用。我们展示了如何动态校对与负反馈实现了近似版本的自适应排序的免疫环境。最后，我们重新审视了细胞群体水平的决策问题，展示了群体和单细胞之间的表型变异性和反馈对于正确决策至关重要。
英文摘要：
Some cells have to take decision based on the quality of surroundings ligands, almost irrespective of their quantity, a problem we name "absolute discrimination". An example of absolute discrimination is recognition of not-self by immune T Cells. We show how the problem of absolute discrimination can be solved by a process called "adaptive sorting". We review several implementations of adaptive sorting, as well as its generic properties such as antagonism. We show how kinetic proofreading with negative feedback implements an approximate version of adaptive sorting in the immune context. Finally, we revisit the decision problem at the cell population level, showing how phenotypic variability and feedbacks between population and single cells are crucial for proper decision.
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