基于磁性纳米粒子聚集体的顺磁性纳米胶囊导向MRI给药系统的计算建模
Computational Modeling of an MRI Guided Drug Delivery System Based on Magnetic Nanoparticle Aggregations for the Navigation of Paramagnetic Nanocapsules
摘要：
提出了一种磁导向药物输送的计算方法，并对流体环境中磁性颗粒的聚集过程进行了比较。该模型的开发用于模拟的磁纳米粒子的聚集模式下的MRI磁线圈的影响。提出了一种计算骨料曳力系数的新方法。实验和数值结果的比较表明，所提出的方法预测聚集体的大小和图案的依赖性，浓度和强度的磁场，以及它们的速度时，颗粒被驱动通过流体的磁梯度。
英文摘要：
A computational method for magnetically guided drug delivery is presented and the results are compared for the aggregation process of magnetic particles within a fluid environment. The model is developed for the simulation of the aggregation patterns of magnetic nanoparticles under the influence of MRI magnetic coils. A novel approach for the calculation of the drag coefficient of aggregates is presented. The comparison against experimental and numerical results from the literature is showed that the proposed method predicts well the aggregations in respect to their size and pattern dependance, on the concentration and the strength of the magnetic field, as well as their velocity when particles are driven through the fluid by magnetic gradients.
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