短杆菌肽孔间膜介导的排斥
Membrane-mediated repulsion between gramicidin pores
摘要：
我们研究了作为肽/脂质比的函数的抗微生物肽短杆菌肽形成的含有孔的两性离子脂质1，2-二月桂酰-sn-甘油-3-磷脂酰胆碱的高度对齐的多层膜的X射线散射信号。我们能够获得的孔隙流体的结构因子的信息，然后产生的双层的平面中的孔隙之间的相互作用潜力。除了一个硬核的半径接近孔的几何半径，我们发现了一个排斥指数脂质介导的相互作用，衰减长度为2.5 μ m，振幅随孔浓度的增加而减小，与疏水匹配假设一致。在稀体系中，这种相互作用的接触值约为30 k $_B$ T。对于插入由非离子表面活性剂五乙二醇单十二烷基醚形成的双层内的短杆菌肽孔，获得了类似的结果。
英文摘要：
We investigated the X-ray scattering signal of highly aligned multilayers of the zwitterionic lipid 1,2-dilauroyl-sn-glycero-3-phosphatidylcholine containing pores formed by the antimicrobial peptide gramicidin as a function of the peptide/lipid ratio. We are able to obtain information on the structure factor of the pore fluid, which then yields the interaction potential between pores in the plane of the bilayers. Aside from a hard core with a radius close to the geometric radius of the pore, we find a repulsive exponential lipid-mediated interaction with a decay length of 2.5 Å and an amplitude that decreases with the pore concentration, in agreement with the hydrophobic matching hypothesis. In dilute systems, the contact value of this interaction is about 30 k$_B$T. Similar results are obtained for gramicidin pores inserted within bilayers formed by the nonionic surfactant pentaethylene glycol monododecyl ether.
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