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arXiv 1503.07248q-bio.NCcond-mat.stat-mech
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有色噪声和记忆效应对形式发放神经元模型的影响

Colored noise and memory effects on formal spiking neuron models

L. A. da Silva, R. D. Vilela

摘要:

简化的神经元模型捕捉了一般神经元电活动的本质,除了从计算的角度来看,与更高维的模型(如Hodgkin-Huxley模型)相比更有趣之外。在这项工作中,我们提出了一个广义的共振和火灾模型描述的广义朗之万方程,考虑到记忆效应和有色噪声。我们进行了全面的数值分析,以研究所提出的模型的动力学和点过程统计,突出有趣的新功能,如:i)非单调行为(峰结构的出现,通过色噪声特征时间尺度的选择而增强)作为记忆特征时间尺度的函数的变异系数(CV),ii)色噪声引起的CV中的移位,以及iii)由于记忆诱导的阈下振荡而在峰间间隔(ISI)分布中出现和抑制多峰。此外,在噪声诱导的尖峰制度,我们研究如何记忆和色噪声影响的相干共振(CR)现象。我们发现,对于足够长的记忆,CR不仅被抑制,而且CV $\times$噪声强度曲线的最小值,其特征在于CR的存在可能被最大值所取代。上述特征允许将记忆和有色噪声之间的相互作用解释为对神经元变异性的有效控制机制。由于ISI分布中的可变性和非平凡的时间模式在生物细胞中是普遍存在的,我们希望本模型可以用于模拟神经元的真实方面。

英文摘要:

Simplified neuronal models capture the essence of the electrical activity of a generic neuron, besides being more interesting from the computational point of view when compared to higher dimensional models such as the Hodgkin-Huxley one. In this work, we propose a generalized resonate-and-fire model described by a generalized Langevin equation that takes into account memory effects and colored noise. We perform a comprehensive numerical analysis to study the dynamics and the point process statistics of the proposed model, highlighting interesting new features like: i) non-monotonic behavior (emergence of peak structures, enhanced by the choice of colored noise characteristic time-scale) of the coefficient of variation (CV) as a function of memory characteristic time-scale, ii) colored noise-induced shift in the CV, and iii) emergence and suppression of multimodality in the interspike interval (ISI) distribution due to memory-induced subthreshold oscillations. Moreover, in the noise-induced spike regime, we study how memory and colored noise affects the coherence resonance (CR) phenomenon. We found that for sufficiently long memory, CR is not only suppressed, but also the minimum of the CV $\times$ noise intensity curve that characterizes the presence of CR may be replaced by a maximum. The aforementioned features allow to interpret the interplay between memory and colored noise as an effective control mechanism to neuronal variability. Since both variability and non-trivial temporal patterns in the ISI distribution are ubiquitous in biological cells, we hope the present model can be useful in modeling real aspects of neurons.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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