高功能自闭症患者功能连接的大脑子网络的重组
Reorganization of functionally connected brain subnetworks in high-functioning autism
摘要：
背景资料：先前的功能连接研究发现，自闭症谱系障碍（ASD）患者的大脑存在连接性不足和连接性过度的现象。在这里，我们研究了高功能ASD患者在自由观看包含社交线索和互动的电影时功能性大脑子网络的异常。方法：13名ASD患者和13名配对对照者在功能磁共振成像期间观看68分钟的电影。对于每一个主题，我们计算皮尔逊的血液动力学的时间过程中的每对6毫米各向同性体素之间的相关性。从全脑功能网络，我们推导出个人和群体层次的子网络，使用图论。然后计算所有受试者对之间的标度包容度，以估计每个子网络的连接结构的受试者间相似性。另外27名来自ABIDE静息状态数据库的ASD患者被纳入，以测试结果的可重复性。结果：组间差异观察到的默认模式和腹-颞-边缘（ventro-temporal-limbic，VES）子网络的组成。杏仁核、纹状体、丘脑、海马旁回、梭状回和颞下回是海马神经网络的组成部分。此外，主题对之间的子网络相似性与自闭症商测量的症状严重性的相似性显着相关。在对照组以及具有ADI-R和ADOS评分的再现性数据集中也观察到了这种相关性。结论：ASD患者的功能子网络重组澄清了低连接和高连接的混合结果。重要的是，只有网络子网络的功能组织才能作为个体间相似性的标志，这些相似性与所有参与者的行为指标共同变化。这些发现表明腹颞叶和边缘系统在自闭症中起着关键作用。
英文摘要：
Background: Previous functional connectivity studies have found both hypo- and hyper-connectivity in brains of individuals having autism spectrum disorder (ASD). Here we studied abnormalities in functional brain subnetworks in high-functioning individuals with ASD during free viewing of a movie containing social cues and interactions. Methods: Thirteen subjects with ASD and 13 matched-pair controls watched a 68 minutes movie during functional magnetic resonance imaging. For each subject, we computed Pearson`s correlation between haemodynamic time-courses of each pair of 6-mm isotropic voxels. From the whole-brain functional networks, we derived individual and group-level subnetworks using graph theory. Scaled inclusivity was then calculated between all subject pairs to estimate intersubject similarity of connectivity structure of each subnetwork. Additional 27 individuals with ASD from the ABIDE resting-state database were included to test the reproducibility of the results. Results: Between-group differences were observed in the composition of default-mode and a ventro-temporal-limbic (VTL) subnetwork. The VTL subnetwork included amygdala, striatum, thalamus, parahippocampal, fusiform, and inferior temporal gyri. Further, VTL subnetwork similarity between subject pairs correlated significantly with similarity of symptom gravity measured with autism quotient. This correlation was observed also within the controls, and in the reproducibility dataset with ADI-R and ADOS scores. Conclusions: Reorganization of functional subnetworks in individuals with ASD clarifies the mixture of hypo- and hyper-connectivity findings. Importantly, only the functional organization of the VTL subnetwork emerges as a marker of inter-individual similarities that co-vary with behavioral measures across all participants. These findings suggest a pivotal role of ventro-temporal and limbic systems in autism.
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