钙离子介导的视交叉上核神经元细胞膜活性与时钟基因表达偶联模型
A model of calcium-mediated coupling between membrane activity and clock gene expression in neurons of the suprachiasmatic nucleus
摘要：
视交叉上核（SCN）细胞膜电活动的节律对于昼夜节律计时系统的功能至关重要，其特征在于所谓的时钟基因的表达。细胞内Ca $^{2+}$离子似乎至少部分地将SCN神经元的电活动与时钟基因的表达联系起来。在本文中，我们介绍了一个简单的数学模型，描述连接膜活性的一个基因的转录的反馈机制的基础上的细胞内钙离子的动力学。
英文摘要：
Rhythms in electrical activity in the membrane of cells in the suprachiasmatic nucleus (SCN) are crucial for the function of the circadian timing system, which is characterized by the expression of the so-called clock genes. Intracellular Ca$^{2+}$ ions seem to connect, at least in part, the electrical activity of SCN neurons with the expression of clock genes. In this paper, we introduce a simple mathematical model describing the linking of membrane activity to the transcription of one gene by means of a feedback mechanism based on the dynamics of intracellular calcium ions.
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