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arXiv 1502.05073math.NAcs.NA

正则化牛顿方法用于相位对比断层成像中的同时Radon反演和相位恢复

Regularized Newton methods for simultaneous Radon inversion and phase retrieval in phase contrast tomography

Institute for Numerical and Applied Mathematics / Institute for X-Ray Physics(数值与应用数学研究所 / X射线物理研究所)

Simon Maretzke

AI总结:

本文提出正则化牛顿方法解决相位对比断层成像中的非线性病态反演问题,通过分析数学结构,结合近场和远场极限,实现同时进行断层和相位重建,提高稳定性。

摘要:

受相干同步辐射光源的发展推动,相位对比断层成像允许从不同入射角记录的X射线散射强度中恢复未知样品复折射率的三维变化。通过衍射自由空间传播的传输波场,该方法不仅对吸收敏感,还对由样品引起的折射相位移敏感,允许对准透明样品如生物细胞进行三维纳米级成像。然而,从观测数据重建样品结构是一个算法上具有挑战性的非线性病态反问题,主要由于波场检测中相位信息的丢失。本文开发了正则化牛顿方法来解决这一断层相位恢复问题,基于对其数学结构的详细分析。我们考虑了近场或弗里塞尔区域,其特征是样品与探测器之间的传播长度适中,以及远场极限,其中传播由傅里叶变换支配。在前者设置中,所选牛顿型方法获得优秀的数值重建,补充了新的理论结果,表明单个探测器距离的测量足以唯一恢复样品的折射和吸收。所提出的算法同时进行断层和相位重建,通过利用不同入射角下记录的衍射图案之间的相关性,稳定了后者。

英文摘要:

Promoted by the advent of coherent synchrotron light sources, phase contrast tomography allows to resolve three-dimensional variations of an unknown sample's complex refractive index from scattering intensities recorded at different incident angles of an X-ray beam. By diffractive free-space propagation of the transmitted wave field, this method is sensitive not only to absorption but also to refractive phase shifts induced by the specimen, permitting three-dimensional nanoscale imaging of quasi-transparent samples such as biological cells. However, the reconstruction of the specimen structure from the observed data constitutes an algorithmically challenging nonlinear ill-posed inverse problem, mainly due to the characteristic loss of phase information in the detection of the wave field. In this work, regularized Newton methods are developed for the solution of this tomographic phase retrieval problem, based on a detailed analysis of its mathematical structure. We consider both the near-field- or Fresnel regime characterized by a moderate propagation length between sample and detector and the far-field limit of large detector distances, where propagation is governed by the Fourier transform. In the former setting, excellent numerical reconstructions are obtained via the chosen Newton-type approach, supplemented by novel theoretical results stating that measurements from a single detector distance are sufficient to uniquely recover both refraction and absorption of a sample. The proposed algorithm simultaneously performs tomographic- and phase reconstruction, which is found to stabilize the latter by exploiting correlations between the diffraction patterns recorded under different incident angles.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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