利用波前整形通过散射颅骨进行细胞信号通路的光遗传学控制
Optogenetic control of cell signaling pathway through scattering skull using wavefront shaping
摘要：
我们介绍了一种非侵入性的方法，通过使用波前整形的高度散射颅骨组织在生物细胞中进行光遗传学调控。使用空间光调制器系统地控制入射光的波前，以克服小鼠颅骨层中的多重光散射并将光聚焦在靶细胞上。我们表明，照明与成形波使时空调节细胞内钙离子水平在单个细胞水平。
英文摘要：
We introduce a non-invasive approach for optogenetic regulation in biological cells through highly scattering skull tissue using wavefront shaping. The wavefront of the incident light was systematically controlled using a spatial light modulator in order to overcome multiple light-scattering in a mouse skull layer and to focus light on the target cells. We demonstrate that illumination with shaped waves enables spatiotemporal regulation of intracellular Ca2+ level at the individual-cell level.
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