This article is concerned with simultaneous tests on linear regression coefficients in high-dimensional settings. When the dimensionality is larger than the sample size, the classic $F$-test is not applicable since the sample covariance matrix is not invertible. In order to overcome this issue, both Goeman, Finos and van Houwelingen (2011) and Zhong and Chen (2011) proposed their test procedures after excluding the $(\X^{'}\X)^{-1}$ term in $F$-statistics. However, both these two test are not invariant under the group of scalar transformations. In order to treat those variables in a `fair' way, we proposed a new test statistic and establish its asymptotically normal under certain mild conditions. Simulation studies showed that our test procedure performs very well in many cases.
Varying coefficient regression is a flexible technique for modeling data where the coefficients are functions of some effect-modifying parameter, often time or location in a certain domain. While there are a number of methods for variable selection in a varying coefficient regression model, the existing methods are mostly for global selection, which includes or excludes each covariate over the entire domain. Presented here is a new local adaptive grouped regularization (LAGR) method for local variable selection in spatially varying coefficient linear and generalized linear regression. LAGR sel…
This paper considers the quantile regression approach for partially linear spatial autoregressive models with possibly varying coefficients. B-spline is employed for the approximation of varying coefficients. The instrumental variable quantile regression approach is employed for parameter estimation. The rank score tests are developed for hypotheses on the coefficients, including the hypotheses on the non-varying coefficients and the constancy of the varying coefficients. The asymptotic properties of the proposed estimators and test statistics are both established. Monte Carlo simulations are …
It is a relatively well-known fact that in problems of Bayesian model selection improper priors should, in general, be avoided. In this paper we derive a proper and parsimonious uniform prior for regression coefficients. We then use this prior to derive the corresponding evidence values of the regression models under consideration. By way of these evidence values one may proceed to compute the posterior probabilities of the competing regression models.
This paper develops a novel spatial quantile function-on-scalar regression model, which studies the conditional spatial distribution of a high-dimensional functional response given scalar predictors. With the strength of both quantile regression and copula modeling, we are able to explicitly characterize the conditional distribution of the functional or image response on the whole spatial domain. Our method provides a comprehensive understanding of the effect of scalar covariates on functional responses across different quantile levels and also gives a practical way to generate new images for …
In this article, we propose a new nonparametric data analysis tool, which we call nonparametric modal regression, to investigate the relationship among interested variables based on estimating the mode of the conditional density of a response variable Y given predictors X. The nonparametric modal regression is distinguished from the conventional nonparametric regression in that, instead of the conditional average or median, it uses the "most likely" conditional values to measures the center. Better prediction performance and robustness are two important characteristics of nonparametric modal r…
We consider inference procedures, conditional on an observed ancillary statistic, for regression coefficients under a linear regression setup where the unknown error distribution is specified nonparametrically. We establish conditional asymptotic normality of the regression coefficient estimators under regularity conditions, and formally justify the approach of plugging in kernel-type density estimators in conditional inference procedures. Simulation results show that the approach yields accurate conditional coverage probabilities when used for constructing confidence intervals. The plug-in ap…
We propose a new class of estimators of the multivariate response linear regression coefficient matrix that exploits the assumption that the response and predictors have a joint multivariate Normal distribution. This allows us to indirectly estimate the regression coefficient matrix through shrinkage estimation of the parameters of the inverse regression, or the conditional distribution of the predictors given the responses. We establish a convergence rate bound for estimators in our class and we study two examples. The first example estimator exploits an assumption that the inverse regression…
A scalar-response functional model describes the association between a scalar response and a set of functional covariates. An important problem in the functional data literature is to test the nullity or linearity of the effect of the functional covariate in the context of scalar-on-function regression. This article provides an overview of the existing methods for testing both the null hypotheses that there is no relationship and that there is a linear relationship between the functional covariate and scalar response, and a comprehensive numerical comparison of their performance. The methods a…
In a multiple linear regression model, the algebraic formula of the decomposition theorem explains the relationship between the univariate regression coefficient and partial regression coefficient using geometry. It was found that univariate regression coefficients are decomposed into their respective partial regression coefficients according to the parallelogram rule. Multicollinearity is analyzed with the help of the decomposition theorem. It was also shown that it is a sample phenomenon that the partial regression coefficients of important explanatory variables are not significant, but the …
Confidence ellipsoids for linear regression coefficients are constructed by observations from a mixture with varying concentrations. Two approaches are discussed. The first one is the nonparametric approach based on the weighted least squares technique. The second one is an approximate maximum likelihood estimation with application of the EM-algorithm for the estimates calculation.
We develop a modeling framework for dynamic function-on-scalars regression, in which a time series of functional data is regressed on a time series of scalar predictors. The regression coefficient function for each predictor is allowed to be dynamic, which is essential for applications where the association between predictors and a (functional) response is time-varying. For greater modeling flexibility, we design a nonparametric reduced-rank functional data model with an unknown functional basis expansion, which is data-adaptive and, unlike most existing methods, modeled as unknown for appropr…
Classical finite mixture regression is useful for modeling the relationship between scalar predictors and scalar responses arising from subpopulations defined by the differing associations between those predictors and responses. Here we extend the classical finite mixture regression model to incorporate functional predictors by taking a wavelet-based approach in which we represent both the functional predictors and the component-specific coefficient functions in terms of an appropriate wavelet basis. In the wavelet representation of the model, the coefficients corresponding to the functional c…
Complex statistical models such as scalar-on-image regression often require strong assumptions to overcome the issue of non-identifiability. While in theory it is well understood that model assumptions can strongly influence the results, this seems to be underappreciated, or played down, in practice. The article gives a systematic overview of the main approaches for scalar-on-image regression with a special focus on their assumptions. We categorize the assumptions and develop measures to quantify the degree to which they are met. The impact of model assumptions and the practical usage of the p…
We propose an adaptive confidence interval procedure (CIP) for the coefficients in the normal linear regression model. This procedure has a frequentist coverage rate that is constant as a function of the model parameters, yet provides smaller intervals than the usual interval procedure, on average across regression coefficients. The proposed procedure is obtained by defining a class of CIPs that all have exact $1-α$ frequentist coverage, and then selecting from this class the procedure that minimizes a prior expected interval width. Such a procedure may be described as "frequentist, assisted b…
Quantile regression provides a consistent approach to investigating the association between covariates and various aspects of the distribution of the response beyond the mean. When the regression covariates are measured with errors, measurement error (ME) adjustment steps are needed for valid inference. This is true for both scalar and functional covariates. Here, we propose extending the Bayesian measurement error and Bayesian quantile regression literature to allow for available covariates prone to potential complex measurement errors. Our approach uses the Generalized Asymmetric Laplace (GA…
Linear regression is a frequently used tool in statistics, however, its validity and interpretability relies on strong model assumptions. While robust estimates of the coefficients' covariance extend the validity of hypothesis tests and confidence intervals, a clear interpretation of the coefficients is lacking if the mean structure of the model is miss-specified. We therefore suggest a new intuitive and mathematical rigorous interpretation of the coefficients that is independent from specific model assumptions. It relies on a new population based measure of association. The idea is to quantif…
We develop a fully Bayesian framework for function-on-scalars regression with many predictors. The functional data response is modeled nonparametrically using unknown basis functions, which produces a flexible and data-adaptive functional basis. We incorporate shrinkage priors that effectively remove unimportant scalar covariates from the model and reduce sensitivity to the number of (unknown) basis functions. For variable selection in functional regression, we propose a decision theoretic posterior summarization technique, which identifies a subset of covariates that retains nearly the predic…
Quantile regression has been successfully used to study heterogeneous and heavy-tailed data. Varying-coefficient models are frequently used to capture changes in the effect of input variables on the response as a function of an index or time. In this work, we study high-dimensional varying-coefficient quantile regression models and develop new tools for statistical inference. We focus on development of valid confidence intervals and honest tests for nonparametric coefficients at a fixed time point and quantile, while allowing for a high-dimensional setting where the number of input variables e…
Competing risk data appear widely in modern biomedical research. Cause-specific hazard models are often used to deal with competing risk data in the past two decades. There is no current study on the kernel likelihood method for the cause-specific hazard model with time-varying coefficients. We propose to use the local partial log-likelihood approach for nonparametric time-varying coefficient estimation. Simulation studies demonstrate that our proposed nonparametric kernel estimator has a good performance under assumed finite sample settings. Finally, we apply the proposed method to analyze a …
The development and use of dimension reduction methods is prevalent in modern statistical literature. This paper reviews a class of dimension reduction techniques which aim to simultaneously select relevant predictors and find clusters within them which share a common effect on the response. Such methods have been shown to have superior performance relative to OLS estimates and the lasso [Tibshirani, 1996] especially when multicollinearity in the predictors is present. Their applications, which include genetics, epidemiology, and fMRI studies, are also discussed.
Meta-regression is often used to form hypotheses about what is associated with heterogeneity in a meta-analysis and to estimate the extent to which effects can vary between cohorts and other distinguishing factors. However, study-level variables, called moderators, that are available and used in the meta-regression analysis will rarely explain all of the heterogeneity. Therefore, measuring and trying to understand residual heterogeneity is still important in a meta-regression, although it is not clear how some heterogeneity measures should be used in the meta-regression context. The coefficien…
Motivated by recent data analyses in biomedical imaging studies, we consider a class of image-on-scalar regression models for imaging responses and scalar predictors. We propose using flexible multivariate splines over triangulations to handle the irregular domain of the objects of interest on the images, as well as other characteristics of images. The proposed estimators of the coefficient functions are proved to be root-n consistent and asymptotically normal under some regularity conditions. We also provide a consistent and computationally efficient estimator of the covariance function. Asym…
Generalized estimating equation (GEE) is widely adopted for regression modeling for longitudinal data, taking account of potential correlations within the same subjects. Although the standard GEE assumes common regression coefficients among all the subjects, such an assumption may not be realistic when there is potential heterogeneity in regression coefficients among subjects. In this paper, we develop a flexible and interpretable approach, called grouped GEE analysis, to modeling longitudinal data with allowing heterogeneity in regression coefficients. The proposed method assumes that the sub…
This paper presents tests to formally choose between regression models using different derivatives of a functional covariate in scalar-on-function regression. We demonstrate that for linear regression, models using different derivatives can be nested within a model that includes point-impact effects at the end-points of the observed functions. Contrasts can then be employed to test the specification of different derivatives. When nonlinear regression models are defined, we apply a $J$ test to determine the statistical significance of the nonlinear structure between a functional covariate and a…
Many data producers seek to provide users access to confidential data without unduly compromising data subjects' privacy and confidentiality. One general strategy is to require users to do analyses without seeing the confidential data; for example, analysts only get access to synthetic data or query systems that provide disclosure-protected outputs of statistical models. With synthetic data or redacted outputs, the analyst never really knows how much to trust the resulting findings. In particular, if the user did the same analysis on the confidential data, would regression coefficients of inte…
Statistical methods relating tensor predictors to scalar outcomes in a regression model generally vectorize the tensor predictor and estimate the coefficients of its entries employing some form of regularization, use summaries of the tensor covariate, or use a low dimensional approximation of the coefficient tensor. However, low rank approximations of the coefficient tensor can suffer if the true rank is not small. We propose a tensor regression framework which assumes a soft version of the parallel factors (PARAFAC) approximation. In contrast to classic PARAFAC, where each entry of the coeffi…
Scalar-on-image regression aims to investigate changes in a scalar response of interest based on high-dimensional imaging data. We propose a novel Bayesian nonparametric scalar-on-image regression model that utilises the spatial coordinates of the voxels to group voxels with similar effects on the response to have a common coefficient. We employ the Potts-Gibbs random partition model as the prior for the random partition in which the partition process is spatially dependent, thereby encouraging groups representing spatially contiguous regions. In addition, Bayesian shrinkage priors are utilise…
In this paper we introduce a new methodology to determine an optimal coefficient of penalized functional regression. We assume the dependent, independent variables and the regression coefficients are functions of time and error dynamics follow a stochastic differential equation. First we construct our objective function as a time dependent residual sum of square and then minimize it with respect to regression coefficients subject to different error dynamics such as LASSO, group LASSO, fused LASSO and cubic smoothing spline. Then we use Feynman-type path integral approach to determine a Schrödi…
In high-dimensional regression modelling, the number of candidate covariates to be included in the predictor is quite large, and variable selection is crucial. In this work, we propose a new penalty able to guarantee both sparse variable selection, i.e. exactly zero regression coefficient estimates, and quasi-unbiasedness for the coefficients of 'selected' variables in high dimensional regression models. Simulation results suggest that our proposal performs no worse than its competitors while always ensuring that the solution is unique.
We consider the multivariate response regression problem with a regression coefficient matrix of low, unknown rank. In this setting, we analyze a new criterion for selecting the optimal reduced rank. This criterion differs notably from the one proposed in Bunea, She and Wegkamp [7] in that it does not require estimation of the unknown variance of the noise, nor depends on a delicate choice of a tuning parameter. We develop an iterative, fully data-driven procedure, that adapts to the optimal signal to noise ratio. This procedure finds the true rank in a few steps with overwhelming probability.…
In genetic studies, not only can the number of predictors obtained from microarray measurements be extremely large, there can also be multiple response variables. Motivated by such a situation, we consider semiparametric dimension reduction methods in sparse multivariate regression models. Previous studies on joint variable and rank selection have focused on parametric models while here we consider the more challenging varying-coefficient models which make the investigation on nonlinear interactions of variables possible. Spline approximation, rank constraints and concave group penalties are u…
Spatial autocorrelation analysis is the basis for spatial autoregressive modeling. However, the relationships between spatial correlation coefficients and spatial regression models are not yet well clarified. The paper is devoted to explore the deep structure of spatial regression coefficients. By means of mathematical reasoning, a pair of formulae of canonical spatial regression coefficients are derived from a general spatial regression model based on standardized variables. The spatial auto- and lag-regression coefficients are reduced to a series of statistic parameters and measurements, inc…
Wearable devices such as the ActiGraph are now commonly used in health studies to monitor or track physical activity. This trend aligns well with the growing need to accurately assess the effects of physical activity on health outcomes such as obesity. When accessing the association between these device-based physical activity measures with health outcomes such as body mass index, the device-based data is considered functions, while the outcome is a scalar-valued. The regression model applied in these settings is the scalar-on-function regression (SoFR). Most estimation approaches in SoFR assu…
