We propose a general, modular method for significance testing of groups (or clusters) of variables in a high-dimensional linear model. In presence of high correlations among the covariables, due to serious problems of identifiability, it is indispensable to focus on detecting groups of variables rather than singletons. We propose an inference method which allows to build in hierarchical structures. It relies on repeated sample splitting and sequential rejection, and we prove that it asymptotically controls the familywise error rate. It can be implemented on any collection of clusters and leads to improved power in comparison to more standard non-sequential rejection methods. We complete the theoretical analysis with empirical results for simulated and real data.
Closed testing and partitioning are recognized as fundamental principles of familywise error control. In this paper, we argue that sequential rejection can be considered equally fundamental as a general principle of multiple testing. We present a general sequentially rejective multiple testing procedure and show that many well-known familywise error controlling methods can be constructed as special cases of this procedure, among which are the procedures of Holm, Shaffer and Hochberg, parallel and serial gatekeeping procedures, modern procedures for multiple testing in graphs, resampling-based …
We present a sequential Monte Carlo sampler variant of the partial rejection control algorithm, and show that this variant can be considered as a sequential Monte Carlo sampler with a modified mutation kernel. We prove that the new sampler can reduce the variance of the incremental importance weights when compared with standard sequential Monte Carlo samplers. We provide a study of theoretical properties of the new algorithm, and make connections with some existing algorithms. Finally, the sampler is adapted for application under the challenging "likelihood free," approximate Bayesian computat…
If uncorrelated random variables have a common expected value and decreasing variances then the variance of a sample mean is decreasing with the number of observations. Unfortunately, this natural and desirable Variance Reduction Property (VRP) by augmenting data is not automatically inherited by Ordinary Least Squares (OLS) estimators of parameters. In the paper we find conditions for the OLS to have the VRP. In the case of a straight line regression we show that the OLS estimators of intercept and slope have the VRP if the design points are increasing. This also holds true for alternating tw…
While traditional multiple testing procedures prohibit adaptive analysis choices made by users, Goeman and Solari (2011) proposed a simultaneous inference framework that allows users such flexibility while preserving high-probability bounds on the false discovery proportion (FDP) of the chosen set. In this paper, we propose a new class of such simultaneous FDP bounds, tailored for nested sequences of rejection sets. While most existing simultaneous FDP bounds are based on closed testing using global null tests based on sorted p-values, we additionally consider the setting where side informatio…
Applied statisticians use sequential regression procedures to produce a ranking of explanatory variables and, in settings of low correlations between variables and strong true effect sizes, expect that variables at the very top of this ranking are truly relevant to the response. In a regime of certain sparsity levels, however, three examples of sequential procedures--forward stepwise, the lasso, and least angle regression--are shown to include the first spurious variable unexpectedly early. We derive a rigorous, sharp prediction of the rank of the first spurious variable for these three proced…
In many surveys inexpensive auxiliary variables are available that can help us to make more precise estimation about the main variable. Using auxiliary variable has been extended by regression estimators for rare and cluster populations. In conventional regression estimator it is assumed that the mean of auxiliary variable in the population is known. In many surveys we don't have such wide information about auxiliary variable. In this paper we present a multi-phase variant of two-stage sequential sampling based on an inexpensive auxiliary variable associated with the survey variable in the for…
We consider a multiple hypothesis testing setting where the hypotheses are ordered and one is only permitted to reject an initial contiguous block, H_1,\dots,H_k, of hypotheses. A rejection rule in this setting amounts to a procedure for choosing the stopping point k. This setting is inspired by the sequential nature of many model selection problems, where choosing a stopping point or a model is equivalent to rejecting all hypotheses up to that point and none thereafter. We propose two new testing procedures, and prove that they control the false discovery rate in the ordered testing setting. …
INRIA（法国国家信息与自动化研究所）；ENS（巴黎高等师范学院）；PSL Research University（巴黎文理研究大学）；Institut de mathématiques de Toulouse（图卢兹数学研究所）；Université Paul Sabatier（保罗·萨巴蒂埃大学）；Laboratoire de mathématiques d’Orsay（奥赛数学实验室）；Université Paris-Sud（巴黎第十一大学）；CNRS（法国国家科学研究中心）；Université Paris-Saclay（巴黎萨克雷大学）
We consider the setting of online linear regression for arbitrary deterministic sequences, with the square loss. We are interested in the aim set by Bartlett et al. (2015): obtain regret bounds that hold uniformly over all competitor vectors. When the feature sequence is known at the beginning of the game, they provided closed-form regret bounds of $2d B^2 \ln T + \mathcal{O}_T(1)$, where $T$ is the number of rounds and $B$ is a bound on the observations. Instead, we derive bounds with an optimal constant of $1$ in front of the $d B^2 \ln T$ term. In the case of sequentially revealed features,…
The main object of investigation in this paper is a very general regression model in optional setting - when an observed process is an optional semimartingale depending on an unknown parameter. It is well-known that statistical data may present an information flow/filtration without usual conditions. The estimation problem is achieved by means of structural least squares (LS) estimates and their sequential versions. The main results of the paper are devoted to the strong consistency of such LS-estimates. For sequential LS-estimates the property of fixed accuracy is proved.
Censored quantile regression (CQR) has become a valuable tool to study the heterogeneous association between a possibly censored outcome and a set of covariates, yet computation and statistical inference for CQR have remained a challenge for large-scale data with many covariates. In this paper, we focus on a smoothed martingale-based sequential estimating equations approach, to which scalable gradient-based algorithms can be applied. Theoretically, we provide a unified analysis of the smoothed sequential estimator and its penalized counterpart in increasing dimensions. When the covariate dimen…
We establish optimal rates for online regression for arbitrary classes of regression functions in terms of the sequential entropy introduced in (Rakhlin, Sridharan, Tewari, 2010). The optimal rates are shown to exhibit a phase transition analogous to the i.i.d./statistical learning case, studied in (Rakhlin, Sridharan, Tsybakov 2013). In the frequently encountered situation when sequential entropy and i.i.d. empirical entropy match, our results point to the interesting phenomenon that the rates for statistical learning with squared loss and online nonparametric regression are the same. In addi…
Corrupted data sets containing noisy or missing observations are prevalent in various contemporary applications such as economics, finance and bioinformatics. Despite the recent methodological and algorithmic advances in high-dimensional multi-response regression, how to achieve scalable and interpretable estimation under contaminated covariates is unclear. In this paper, we develop a new methodology called convex conditioned sequential sparse learning (COSS) for error-in-variables multi-response regression under both additive measurement errors and random missing data. It combines the strengt…
University of California, San Diego（加州大学圣地亚哥分校）；University of California, Berkeley（加州大学伯克利分校）
We propose a new algorithmic framework for sequential hypothesis testing with i.i.d. data, which includes A/B testing, nonparametric two-sample testing, and independence testing as special cases. It is novel in several ways: (a) it takes linear time and constant space to compute on the fly, (b) it has the same power guarantee as a non-sequential version of the test with the same computational constraints up to a small factor, and (c) it accesses only as many samples as are required - its stopping time adapts to the unknown difficulty of the problem. All our test statistics are constructed to b…
We propose a linear-time, single-pass, top-down algorithm for multiple testing on directed acyclic graphs (DAGs), where nodes represent hypotheses and edges specify a partial ordering in which hypotheses must be tested. The procedure is guaranteed to reject a sub-DAG with bounded false discovery rate (FDR) while satisfying the logical constraint that a rejected node's parents must also be rejected. It is designed for sequential testing settings, when the DAG structure is known a priori, but the $p$-values are obtained selectively (such as in a sequence of experiments), but the algorithm is als…
