非平衡传感及其与动力学校正的类比
Nonequilibrium sensing and its analogy to kinetic proofreading
摘要：
对于一个典型的趋化性模型，我们分析了一个非零的亲和力驱动受体的平衡如何影响灵敏度。当受体活性的变化涉及ATP水解时，这种亲和力就会产生。在配体浓度范围内集成的灵敏度被证明是增强的亲和力，提供了一个测量多少能量消耗提高感测。有了这个综合灵敏度，我们可以建立一个有趣的类比与非平衡受体和动力学校对的传感：在综合灵敏度的增加相当于减少的错误在动力学校对。受体的占用率对磷酸化和去磷酸化反应速率反应速率的影响被证明是至关重要的综合灵敏度和亲和力之间的关系。这种影响甚至可能导致非零亲和力降低积分灵敏度的情况，这对应于反校对。
英文摘要：
For a paradigmatic model of chemotaxis, we analyze the effect how a nonzero affinity driving receptors out of equilibrium affects sensitivity. This affinity arises whenever changes in receptor activity involve ATP hydrolysis. The sensitivity integrated over a ligand concentration range is shown to be enhanced by the affinity, providing a measure of how much energy consumption improves sensing. With this integrated sensitivity we can establish an intriguing analogy between sensing with nonequilibrium receptors and kinetic proofreading: the increase in integrated sensitivity is equivalent to the decrease of the error in kinetic proofreading. The influence of the occupancy of the receptor on the phosphorylation and dephosphorylation reaction rates is shown to be crucial for the relation between integrated sensitivity and affinity. This influence can even lead to a regime where a nonzero affinity decreases the integrated sensitivity, which corresponds to anti-proofreading.
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