MEGAHIT：通过简洁的de Bruijn图实现大型复杂宏基因组组装的超快速单节点解决方案
MEGAHIT: An ultra-fast single-node solution for large and complex metagenomics assembly via succinct de Bruijn graph
摘要：
MEGAHIT是一个NGS从头组装器，用于以时间和成本效益的方式组装大型和复杂的宏基因组学数据。它在单个计算节点上分别在44.1小时和99.6小时内完成了252Gbps的土壤宏基因组数据集的组装，有和没有GPU。MEGAHIT将数据作为一个整体进行组装，即，它避免了像分割和标准化这样的预处理，这可能会损害结果的完整性。MEGAHIT生成的组装体比之前的组装体大3倍，具有更长的重叠群N50和平均重叠群长度。55.8%的读段与组装体对齐，比之前高4倍。MEGAHIT的源代码在GPL v3许可下可在https://github.com/voutcn/megahit上免费获得。
英文摘要：
MEGAHIT is a NGS de novo assembler for assembling large and complex metagenomics data in a time- and cost-efficient manner. It finished assembling a soil metagenomics dataset with 252Gbps in 44.1 hours and 99.6 hours on a single computing node with and without a GPU, respectively. MEGAHIT assembles the data as a whole, i.e., it avoids pre-processing like partitioning and normalization, which might compromise on result integrity. MEGAHIT generates 3 times larger assembly, with longer contig N50 and average contig length than the previous assembly. 55.8% of the reads were aligned to the assembly, which is 4 times higher than the previous. The source code of MEGAHIT is freely available at https://github.com/voutcn/megahit under GPLv3 license.
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