胰腺β细胞簇的相干行为
On the coherent behavior of pancreatic beta cell clusters
摘要：
胰腺中的β细胞代表了耦合的生物振荡器的一个例子，其通过通信途径能够同步它们的电活动，从而引起脉动胰岛素释放。在这项工作中，我们数值分析膜电压信号功率密度谱的无标度自相似特性，通过随机动力学模型的胰岛β细胞微调小鼠实验数据。采用代数方法的相干态形式主义，我们展示了如何相干的分子域可以产生适当的功能条件导致一个平行的“相变“现象的场论。
英文摘要：
Beta cells in pancreas represent an example of coupled biological oscillators which via communication pathways, are able to synchronize their electrical activity, giving rise to pulsatile insulin release. In this work we numerically analyze scale free self-similarity features of membrane voltage signal power density spectrum, through a stochastic dynamical model for beta cells in the islets of Langerhans fine tuned on mouse experimental data. Adopting the algebraic approach of coherent state formalism, we show how coherent molecular domains can arise from proper functional conditions leading to a parallelism with "phase transition" phenomena of field theory.
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