家畜的线粒体基因组需要仔细检查
Mitochondrial Genomes of Domestic Animals Need Scrutiny
摘要：
8种常见家畜（牛、狗、山羊、马、猪、绵羊、牦牛和鸡）及其近缘野生祖先或亲属的线粒体DNA（mtDNA）序列已在GenBank中保存了1000多条。然而，很少有人对序列数据的质量进行评估，这严重影响了最初的结论。在此，我们进行了系统发育调查，这些完整或接近完整的mtDNA序列的基础上mtDNA单倍型类群树的8种动物。我们发现，14.5%（194/1342）的mtDNA序列中存在人工重组、突变过剩和幻影突变等错误，应予以谨慎对待。最后对今后家畜mtDNA研究提出了一些建议。
英文摘要：
More than 1000 complete or near-complete mitochondrial DNA (mtDNA) sequences have been deposited in GenBank for eight common domestic animals (i.e. cattle, dog, goat, horse, pig, sheep, yak and chicken) and their close wild ancestors or relatives. Nevertheless, few efforts have been performed to evaluate the sequence data quality, which heavily impact the original conclusion. Herein, we conducted a phylogenetic survey of these complete or near-complete mtDNA sequences based on mtDNA haplogroup trees for the eight animals. We show that, errors due to artificial recombination, surplus of mutations, and phantom mutations, do exist in 14.5% (194/1342) of mtDNA sequences and shall be treated with wide caution. We propose some caveats for mtDNA studies of domestic animals in the future.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
