质谱法--生长激素测定的一种新方法
Mass Spectrometry-An Alternative in Growth Hormone Measurement
摘要：
生长激素（GH）是一组密切相关的蛋白质亚型。在临床实践中，市售配体结合测定之间的测试结果不一致仍然是一个持续的问题，并且关于不同形式的特定功能的不完整知识留下了适当的被测变量的不确定性。质谱法有望成为一种前进的方式。它不仅能够为当前GH测试的校准提供SI可追溯的参考值，而且还提供了一种独立的方法来高度可靠地对单个GH异构体进行质量选择性定量。这种能力也可以增加兴奋剂控制的可靠性。文章指出了为什么和如何。
英文摘要：
Growth hormone (GH) constitutes a set of closely related protein isoforms. In clinical practice, the disagreement of test results between commercially available ligand-binding assays is still an ongoing issue, and incomplete knowledge about the particular function of the different forms leaves an uncertainty of what should be the appropriate measurand. Mass spectrometry is promising to be a way forward. Not only is it capable of providing SI-traceable reference values for the calibration of current GH-tests, but it also offers an independent approach to highly reliable mass-selective quantification of individual GH-isoforms. This capability may add to reliability in doping control too. The article points out why and how.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
