TB-HIV症状和治疗的建模
Modeling TB-HIV syndemic and treatment
摘要：
结核病（TB）和人类免疫缺陷病毒（HIV）可以被认为是致命的人类综合症。在这篇文章中，我们制定了结核病和艾滋病毒传播动力学模型。该模型考虑了结核病和获得性免疫缺陷综合征（艾滋病）治疗的个人只有一种传染病或两者兼而有之。确定了基本再生产数和平衡点，并分析了稳定性。通过模拟，我们表明，对仅感染结核病的个体进行结核病治疗可以减少结核病和艾滋病毒/艾滋病合并感染的个体数量，并减少疾病（结核病和艾滋病）引起的死亡。类似地，对仅患有艾滋病的个体的治疗也减少了合并感染个体的数量。此外，对处于结核病活动期和潜伏期的合并感染个体进行结核病治疗，意味着从HIV阳性转变为AIDS的个体数量减少。
英文摘要：
Tuberculosis (TB) and human immunodeficiency virus (HIV) can be considered a deadly human syndemic. In this article, we formulate a model for TB and HIV transmission dynamics. The model considers both TB and acquired immune deficiency syndrome (AIDS) treatment for individuals with only one of the infectious diseases or both. The basic reproduction number and equilibrium points are determined and stability is analyzed. Through simulations, we show that TB treatment for individuals with only TB infection reduces the number of individuals that become co-infected with TB and HIV/AIDS, and reduces the diseases (TB and AIDS) induced deaths. Analogously, the treatment of individuals with only AIDS also reduces the number of co-infected individuals. Further, TB-treatment for co-infected individuals in the active and latent stage of TB disease, implies a decrease of the number of individuals that passes from HIV-positive to AIDS.
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