来自通过纳米孔的驱动移位的解卷积链不均匀性
Deconvoluting chain heterogeneities from driven translocation through a nano-pore
摘要：
本文研究了二维可压缩半柔性链的移位动力学，该链由大小分别为$m$和$n$的刚性链段（$S$）和柔性链段（$F$）交替组成，链长分别为不同的$N$.模型中的自由参数是控制三体相互作用项的弯曲刚度$κ_b$、连续单体之间的FENE（键）势中的弹性常数$k_F$、以及链段长度$m$和$n$和重复单元$p$（$N=m_pn_p$）和溶剂粘度$γ$。我们表明，由于熵势垒的变化和链骨干上的非均匀粘性阻力的各种情况是可能的充分体现在等待时间分布的易位链。这些信息可以被解卷积以提取各种长度尺度下的链的机械性质，因此可以用于基于纳米孔的方法来探测生物分子，例如DNA、RNA和蛋白质。
英文摘要：
We study translocation dynamics of a driven compressible semi-flexible chain consisting of alternate blocks of stiff ($S$) and flexible ($F$) segments of size $m$ and $n$ respectively for different chain length $N$ in two dimension (2D). The free parameters in the model are the bending rigidity $κ_b$ which controls the three body interaction term, the elastic constant $k_F$ in the FENE (bond) potential between successive monomers, as well as the segmental lengths $m$ and $n$ and the repeat unit $p$ ($N=m_pn_p$) and the solvent viscosity $γ$. We demonstrate that due to the change in entropic barrier and the inhomogeneous viscous drag on the chain backbone a variety of scenarios are possible amply manifested in the waiting time distribution of the translocating chain. These information can be deconvoluted to extract the mechanical properties of the chain at various length scales and thus can be used to nanopore based methods to probe bio-molecules, such as DNA, RNA and proteins.
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