基于光机械流共振器的光声生物传感
Opto-Acoustic Biosensing with Optomechanofluidic Resonators
摘要：
光-机械-流体谐振器（OMFRs）是一种独特的光流体平台，可以在完全包含的微流体系统中测量流体和生物分析物的声学特性。通过将光限制在OMFRs的超高Q回音壁模式中，诸如辐射压力和电致伸缩的光学力可以用于致动和感测跨越MHz到GHz频率的结构机械振动。这些振动是混合流体壳模式，夹带任何生物分析物存在于内部。因此，生物分析物现在可以在设备的光机械振动光谱上反映它们的声学特性，除了使用现有的光流体技术进行光学特性测量之外。在这项工作中，我们调查的OMFRs使用计算本征频率分析的声学传感能力。我们分析了OMFR本征频率的灵敏度，以及散装流体相材料的纳米粒子，并提出了方法来提取多个声学参数从多个振动模式。这种光声测量提供的新的信息自由度可能会在不久的将来导致令人惊讶的新传感器应用。
英文摘要：
Opto-mechano-fluidic resonators (OMFRs) are a unique optofluidics platform that can measure the acoustic properties of fluids and bioanalytes in a fully-contained microfluidic system. By confining light in ultra-high-Q whispering gallery modes of OMFRs, optical forces such as radiation pressure and electrostriction can be used to actuate and sense structural mechanical vibrations spanning MHz to GHz frequencies. These vibrations are hybrid fluid-shell modes that entrain any bioanalyte present inside. As a result, bioanalytes can now reflect their acoustic properties on the optomechanical vibrational spectrum of the device, in addition to optical property measurements with existing optofluidics techniques. In this work, we investigate acoustic sensing capabilities of OMFRs using computational eigenfrequency analysis. We analyze the OMFR eigenfrequency sensitivity to bulk fluid-phase materials as well as nanoparticles, and propose methods to extract multiple acoustic parameters from multiple vibrational modes. The new informational degrees-of-freedom provided by such opto-acoustic measurements could lead to surprising new sensor applications in the near future.
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