从粘附膜的一致形状和涨落分析揭示的非简谐势的特征
Signature of a non-harmonic potential as revealed from a consistent shape and fluctuation analysis of an adherent membrane
摘要：
流体膜与支架（可以是平面表面或更复杂的结构）的相互作用是许多系统所固有的-从人工支撑的双层和囊泡到细胞膜。原则上，这些相互作用可以是离散的和蛋白质介导的，也可以是连续的。在后一种情况下，它们出现从无处不在的内在表面相互作用的潜力，以及自然设计的空间贡献的波动膜或从聚合物的糖萼。尽管这些非特异性电位是无所不在的，但从实验和理论的角度来看，它们的描述一直是一个重大挑战。在这里，我们表明，只有通过扩展通常用于治疗这些类型的系统的标准叠加模型，超出通常的谐波水平的描述，才能实现连续相互作用的影响的充分理解。在这个扩展的理论框架的支持下，我们提出了三个独立的，但相互一致的，实验方法来测量相互作用势强度和膜张力。在明确考虑到散粒噪声的性质以及有限的实验分辨率后，获得了与增强理论的极好的一致性，这最终提供了支架附近的膜的行为的连贯视图。
英文摘要：
The interaction of fluid membranes with a scaffold, which can be a planar surface or a more complex structure, is intrinsic to a number of systems - from artificial supported bilayers and vesicles to cellular membranes. In principle, these interactions can be either discrete and protein mediated, or continuous. In the latter case, they emerge from ubiquitous intrinsic surface interaction potentials as well as nature-designed steric contributions of the fluctuating membrane or from the polymers of the glycocalyx. Despite the fact that these nonspecific potentials are omnipresent, their description has been a major challenge from experimental and theoretical points of view. Here we show that a full understanding of the implications of the continuous interactions can be achieved only by expanding the standard superposition models commonly used to treat these types of systems, beyond the usual harmonic level of description. Supported by this expanded theoretical framework, we present three independent, yet mutually consistent, experimental approaches to measure the interaction potential strength and the membrane tension. Upon explicitly taking into account the nature of shot noise as well as of finite experimental resolution, excellent agreement with the augmented theory is obtained, which finally provides a coherent view of the behavior of the membrane in a vicinity of a scaffold.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
