过氧化氢热化学振荡器作为原始RNA复制的驱动器
Hydrogen peroxide thermochemical oscillator as driver for primordial RNA replication
摘要：
本文提出并测试了一种以前未被认识到的机制，用于在生物起源前的地球上驱动复制分子系统。有人提出，无细胞RNA复制的原始汤可能已被驱动的自持振荡热化学反应。为了检验这一假设，选择了一种充分表征的过氧化氢振荡器作为驱动器，并将具有已知缔合和解链动力学的互补RNA链用作底物。一个开放的流动系统模型的自洽，耦合的温度和浓度的演变在一个简单的自催化方案数值求解，它表明，热化学循环驱动复制的RNA链。对于为模拟的示例系统选择的参数的值（可验证地现实的），给定恒定的底物物质供应，在稳态下产生的复制物的平均量是输入量的6.56倍。持续的热化学振荡通过缓慢漂移参数的自发发作的证明，并给出了一个计划的益生元生产的互补RNA链在岩石表面。
英文摘要：
This paper presents and tests a previously unrecognised mechanism for driving a replicating molecular system on the prebiotic earth. It is proposed that cell-free RNA replication in the primordial soup may have been driven by self-sustained oscillatory thermochemical reactions. To test this hypothesis a well-characterised hydrogen peroxide oscillator was chosen as the driver and complementary RNA strands with known association and melting kinetics were used as the substrate. An open flow system model for the self-consistent, coupled evolution of the temperature and concentrations in a simple autocatalytic scheme is solved numerically, and it is shown that thermochemical cycling drives replication of the RNA strands. For the (justifiably realistic) values of parameters chosen for the simulated example system, the mean amount of replicant produced at steady state is 6.56 times the input amount, given a constant supply of substrate species. The spontaneous onset of sustained thermochemical oscillations via slowly drifting parameters is demonstrated, and a scheme is given for prebiotic production of complementary RNA strands on rock surfaces.
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