设计刺激敏感的胶体步行器
Designing stimulus-sensitive colloidal walkers
摘要：
如果受体浓度存在梯度，则可以使具有DNA“腿”的胶体颗粒与表面上的受体可逆地结合，从而使其“行走”。我们使用理论和蒙特卡罗模拟相结合，探讨如何可控的参数，如涂层密度和结合强度，影响这种胶体的动力学。我们发现，热力学和动力学趋势之间的竞争意味着，有一个最佳值，结合强度和运输速度最快的“腿”的数量。使用现有的DNA结合的热力学数据，我们表明如何定向可逆，温度控制运输的胶体步行者可以实现。特别是，目前的研究结果应该有可能设计一种色谱技术，可用于分离胶体与不同的DNA功能化。
英文摘要：
Colloidal particles with DNA `legs' that can bind reversibly to receptors on a surface can be made to `walk' if there is a gradient in receptor concentration. We use a combination of theory and Monte Carlo simulations to explore how controllable parameters, e.g. coating density and binding strength, affect the dynamics of such colloids. We find that competition between thermodynamic and kinetic trends imply that there is an optimal value for both, the binding strength and the number of `legs' for which transport is fastest. Using available thermodynamic data on DNA binding, we indicate how directionally reversible, temperature-controlled transport of colloidal walkers can be achieved. In particular, the present results should make it possible to design a chromatographic technique that can be used to separate colloids with different DNA functionalization.
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