用于多功能流体传感的弹性体二维光栅和半球形光流体腔
Elastomeric 2D Grating and Hemispherical Optofluidic Chamber for Multifunctional Fluidic Sensing
摘要：
我们提出了一种基于弹性体二维（2D）光栅集成在半球形流体腔室的光流体传感器。激光束在穿过圆顶腔室中的光栅和液体之前（反射）和之后（透射）发生衍射。传感机制进行了研究和模拟与有限差分时域（FDTD）的电磁（EM）方法。在实验上，通过分析二维衍射图样的大小、功率和形状，可以高灵敏度地反演液体的折射率、压强和不透明度等多个参数。我们证明，当混合在不同浓度的磷酸盐缓冲盐水（PBS）溶液中时，可以监测葡萄糖浓度。利用该传感器对牛血清白蛋白（BSA）和抗BSA IgG的自由溶液结合进行了检测。这种低成本、多功能、高可靠性的光电流传感器具有作为血液透析等生物流体监测器的潜力。
英文摘要：
We present an optofluidic sensor based on an elastomeric two-dimensional (2D) grating integrated inside a hemispherical fluid chamber. Laser beam is diffracted before (reflection) and after (transmission) going through the grating and liquid in the dome chamber. The sensing mechanism is investigated and simulated with a finite difference time domain (FDTD) based electromagnetic (EM) method. For experiment, by analyzing the size, power and shape of the 2D diffraction patterns, we can retrieve multiple parameters of the liquid including the refractive index, pressure and opacity with high sensitivity. We demonstrate that glucose concentration can be monitored when mixed in different concentrated phosphate buffered saline (PBS) solution. The free-solution binding of bovine serum albumin (BSA) and anti-BSA IgG is detected with this optical sensor. This low-cost, multifunctional and reliable optofluidic sensor has the potential to be used as monitor of biofluid such as blood in hemodialysis.
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