视蛋白与视蛋白:生物技术应用的新材料
Opsin vs opsin: new materials for biotechnological applications
摘要:
对满足早期检测、低侵入性程序和成本效益价值的新诊断方法的需求使技术研究朝向使用生物集成装置,特别是生物传感器。实现这一目标所需的知识是广泛的,从生物化学到电子学,并在电子学的一个新兴分支中进行了总结,称为\textit{proteotronics}。蛋白电子学在这里被应用于陈述来自类型-1和2型视蛋白的电响应的比较分析。特别是,该程序被用作最近发现的视蛋白家族的早期调查,由蓝光激活的蛋白视紫质,BPR。结果揭示了这两个家族的蛋白质之间一些有趣和意想不到的相似之处,表明全局电响应并不严格与类别身份相关。
英文摘要:
The need of new diagnostic methods satisfying, as an early detection, a low invasive procedure and a cost-efficient value, is orienting the technological research toward the use of bio-integrated devices, in particular bio-sensors. The set of know-why necessary to achieve this goal is wide, from biochemistry to electronics and is summarized in an emerging branch of electronics, called \textit{proteotronics}. Proteotronics is here here applied to state a comparative analysis of the electrical responses coming from type-1 and type-2 opsins. In particular, the procedure is used as an early investigation of a recently discovered family of opsins, the proteorhodopsins activated by blue light, BPRs. The results reveal some interesting and unexpected similarities between proteins of the two families, suggesting the global electrical response are not strictly linked to the class identity.
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