协同性可以增强蜂窝信号检测
Cooperativity Can Enhance Cellular Signal Detection
摘要：
大多数感觉细胞使用表面受体来检测环境刺激并启动下游信号。已知感觉受体之间的协同相互作用在增强生化过程的灵敏度方面起着至关重要的作用，例如血红蛋白的氧感测，但协同性是否增强了具有多个受体的系统可以准确快速检测信号的保真度，目前还知之甚少。我们模拟了配体存在下受体小簇的动力学，其中受体独立或协同作用。我们表明，相互作用的强度，以及它是如何耦合到动力学影响的宏观可观测量。与最近的报道相反，我们的分析表明，受体协同性可以增加信噪比，但这种增加取决于信号受体簇的潜在动力学。
英文摘要：
Most sensory cells use surface receptors to detect environmental stimuli and initiate downstream signaling. Cooperative interactions among sensory receptors is known to play a crucial role in enhancing the sensitivity of biochemical processes such as oxygen sensing by hemoglobin, but whether cooperativity enhances the fidelity with which a system with multiple receptors can accurately and quickly detect a signal is poorly understood. We model the kinetics of small clusters of receptors in the presence of ligand, where the receptors act independently or cooperatively. We show that the interaction strength and how it is coupled to the dynamics influences the macroscopic observables. Contrary to recent reports, our analysis shows that receptor cooperativity can increase the signal-to-noise ratio, but this increase depends on the underlying dynamics of the signaling receptor cluster.
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