稳定灵活的葡萄糖稳态系统
Stable and flexible system for glucose homeostasis
摘要：
控制葡萄糖稳态的胰岛由α、β和δ细胞组成。已经观察到，α和β细胞在胰高血糖素和胰岛素（用于增加和降低葡萄糖水平的反调节激素）的释放中产生异相同步，而β和δ细胞在胰岛素和生长抑素的释放中产生同相同步。胰岛细胞之间的相互作用已经被观察了很长时间，尽管它们作为一个整体的生理作用还没有被探索。我们的模型与耦合相位振荡器，结合所观察到的细胞相互作用的同步激素脉冲的胰岛。整合模型表明，β细胞与δ细胞之间的相互作用应该是正的，才能再现β细胞与δ细胞之间的同相同步。该模型还表明，δ细胞帮助胰岛系统灵活地响应葡萄糖环境的变化。
英文摘要：
Pancreatic islets, controlling glucose homeostasis, consist of α, β, and δ cells. It has been observed that α and β cells generate out-of-phase synchronization in the release of glucagon and insulin, counter-regulatory hormones for increasing and decreasing glucose levels, while β and δ cells produce in-phase synchronization in the release of the insulin and somatostatin. Pieces of interactions between the islet cells have been observed for a long time, although their physiological role as a whole has not been explored yet. We model the synchronized hormone pulses of islets with coupled phase oscillators that incorporate the observed cellular interactions. The integrated model shows that the interaction from β to δ cells, of which sign has controversial reports, should be positive to reproduce the in-phase synchronization between β and δ cells. The model also suggests that δ cells help the islet system flexibly respond to changes of glucose environment.
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