用原子力显微镜探测短尺度上的DNA柔性
DNA flexibility on short length scales probed by atomic force microscopy
摘要：
最近有报道称，DNA在短长度尺度上具有异常高的弯曲柔性。我们使用原子力显微镜（AFM）的解决方案，以获得直接估计的DNA弯曲统计尺度下降到一个螺旋圈。DNA的行为似乎是高斯链，并且在超过3个螺旋圈（10.5纳米）的长度尺度上可以用蠕虫状链模型很好地描述。低于这个阈值，AFM数据表现出越来越多的噪音，因为实验的限制。这种噪声可能会隐藏高斯行为的小偏差，但它们几乎不可能是显著的。
英文摘要：
Unusually high bending flexibility has been recently reported for DNA on short length scales. We use atomic force microscopy (AFM) in solution to obtain a direct estimate of DNA bending statistics for scales down to one helical turn. It appears that DNA behaves as a Gaussian chain and is well described by the worm-like chain model at length scales beyond 3 helical turns (10.5nm). Below this threshold, the AFM data exhibit growing noise because of experimental limitations. This noise may hide small deviations from the Gaussian behavior, but they can hardly be significant.
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