纤维蛋白原层内的示踪剂扩散
Tracer diffusion inside fibrinogen layers
摘要:
我们调查的阻碍运动的示踪剂(测试)粒子在拥挤的环境中进行模拟的二维高斯随机游走模型纤维蛋白原单层的不同取向排序。纤维蛋白原分子是显著各向异性的,因此它们可以形成取向有序的结构,类似于在液晶中观察到的取向有序。这项工作的重点是水平的取向顺序(环境拥挤程度)的纤维蛋白原分子内的层和非Fickian字符的扩散过程中移动的领域内的球形示踪剂颗粒之间的依赖关系。结果表明,在一般情况下,粒子运动是亚扩散的,具有强各向异性,其特征随取向序参量、纤维蛋白原浓度和扩散探针半径的变化而显著变化。
英文摘要:
We investigate the obstructed motion of tracer (test) particles in crowded environments by carrying simulations of two-dimensional Gaussian random walk in model fibrinogen monolayers of different orientational ordering. The fibrinogen molecules are significantly anisotropic and therefore they can form structures where orientational ordering, similar to the one observed in nematic liquid crystals, appears. The work focuses on the dependence between level of the orientational order (degree of environmental crowding) of fibrinogen molecules inside a layer and non-Fickian character of the diffusion process of spherical tracer particles moving within the domain. It is shown that in general particles motion is subdiffusive and strongly anisotropic, and its characteristic features significantly change with the orientational order parameter, concentration of fibrinogens and radius of a diffusing probe.
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