In this paper, an iterative method for robust deconvolution with positivity constraints is discussed. It is based on the known variational interpretation of the Richardson-Lucy iterative deconvolution as fixed-point iteration for the minimisation of an information divergence functional under a multiplicative perturbation model. The asymmetric penaliser function involved in this functional is then modified into a robust penaliser, and complemented with a regulariser. The resulting functional gives rise to a fixed point iteration that we call robust and regularised Richardson-Lucy deconvolution. It achieves an image restoration quality comparable to state-of-the-art robust variational deconvolution with a computational efficiency similar to that of the original Richardson-Lucy method. Experiments on synthetic and real-world image data demonstrate the performance of the proposed method.
Most image deblurring methods assume an over-simplistic image formation model and as a result are sensitive to more realistic image degradations. We propose a novel variational framework, that explicitly handles pixel saturation, noise, quantization, as well as non-linear camera response function due to e.g., gamma correction. We show that accurately modeling a more realistic image acquisition pipeline leads to significant improvements, both in terms of image quality and PSNR. Furthermore, we show that incorporating the non-linear response in both the data and the regularization terms of the p…
Natural image statistics exhibit hierarchical dependencies across multiple scales. Representing such prior knowledge in non-factorial latent tree models can boost performance of image denoising, inpainting, deconvolution or reconstruction substantially, beyond standard factorial "sparse" methodology. We derive a large scale approximate Bayesian inference algorithm for linear models with non-factorial (latent tree-structured) scale mixture priors. Experimental results on a range of denoising and inpainting problems demonstrate substantially improved performance compared to MAP estimation or to …
Massachussetts Institute of Technology（麻省理工学院）；New York University（纽约大学）；Facebook Inc.（Facebook公司）
Blind deconvolution has made significant progress in the past decade. Most successful algorithms are classified either as Variational or Maximum a-Posteriori ($MAP$). In spite of the superior theoretical justification of variational techniques, carefully constructed $MAP$ algorithms have proven equally effective in practice. In this paper, we show that all successful $MAP$ and variational algorithms share a common framework, relying on the following key principles: sparsity promotion in the gradient domain, $l_2$ regularization for kernel estimation, and the use of convex (often quadratic) cos…
In this paper, we introduce a variational Bayesian algorithm (VBA) for image blind deconvolution. Our generic framework incorporates smoothness priors on the unknown blur/image and possible affine constraints (e.g., sum to one) on the blur kernel. One of our main contributions is the integration of VBA within a neural network paradigm, following an unrolling methodology. The proposed architecture is trained in a supervised fashion, which allows us to optimally set two key hyperparameters of the VBA model and lead to further improvements in terms of resulting visual quality. Various experiments…
This paper presents a scalable approximate Bayesian method for image restoration using total variation (TV) priors. In contrast to most optimization methods based on maximum a posteriori estimation, we use the expectation propagation (EP) framework to approximate minimum mean squared error (MMSE) estimators and marginal (pixel-wise) variances, without resorting to Monte Carlo sampling. For the classical anisotropic TV-based prior, we also propose an iterative scheme to automatically adjust the regularization parameter via expectation-maximization (EM). Using Gaussian approximating densities wi…
Blind deconvolution is the problem of recovering a sharp image and a blur kernel from a noisy blurry image. Recently, there has been a significant effort on understanding the basic mechanisms to solve blind deconvolution. While this effort resulted in the deployment of effective algorithms, the theoretical findings generated contrasting views on why these approaches worked. On the one hand, one could observe experimentally that alternating energy minimization algorithms converge to the desired solution. On the other hand, it has been shown that such alternating minimization algorithms should f…
Roche Innovation Center Munich（罗氏慕尼黑创新中心）；Technische Universität München（慕尼黑工业大学）；SagivTech LTD.（SagivTech有限公司）
A key challenge in cancer immunotherapy biomarker research is quantification of pattern changes in microscopic whole slide images of tumor biopsies. Different cell types tend to migrate into various tissue compartments and form variable distribution patterns. Drug development requires correlative analysis of various biomarkers in and between the tissue compartments. To enable that, tissue slides are manually annotated by expert pathologists. Manual annotation of tissue slides is a labor intensive, tedious and error-prone task. Automation of this annotation process can improve accuracy and cons…
Heriot-Watt University（赫瑞-瓦特大学）；University of Edinburgh（爱丁堡大学）
Optical endomicroscopy (OEM) is an emerging technology platform with preclinical and clinical imaging applications. Pulmonary OEM via fibre bundles has the potential to provide in vivo, in situ molecular signatures of disease such as infection and inflammation. However, enhancing the quality of data acquired by this technique for better visualization and subsequent analysis remains a challenging problem. Cross coupling between fiber cores and sparse sampling by imaging fiber bundles are the main reasons for image degradation, and poor detection performance (i.e., inflammation, bacteria, etc.).…
Institute of Automation, Chinese Academy of Sciences（中国科学院自动化研究所）；University of Technology, Sydney（悉尼科技大学）；Xiamen University（厦门大学）
It remains a challenge to simultaneously remove geometric distortion and space-time-varying blur in frames captured through a turbulent atmospheric medium. To solve, or at least reduce these effects, we propose a new scheme to recover a latent image from observed frames by integrating a new variational model and distortion-driven spatial-temporal kernel regression. The proposed scheme first constructs a high-quality reference image from the observed frames using low-rank decomposition. Then, to generate an improved registered sequence, the reference image is iteratively optimized using a varia…
University of Cambridge（剑桥大学）；MRC Laboratory of Molecular Biology（MRC分子生物学实验室）
We study the problem of deconvolution for light-sheet microscopy, where the data is corrupted by spatially varying blur and a combination of Poisson and Gaussian noise. The spatial variation of the point spread function (PSF) of a light-sheet microscope is determined by the interaction between the excitation sheet and the detection objective PSF. First, we introduce a model of the image formation process that incorporates this interaction, therefore capturing the main characteristics of this imaging modality. Then, we formulate a variational model that accounts for the combination of Poisson a…
Microsoft Research（微软研究院）；Northwestern Polytechnical University（西北工业大学）
Blind deconvolution involves the estimation of a sharp signal or image given only a blurry observation. Because this problem is fundamentally ill-posed, strong priors on both the sharp image and blur kernel are required to regularize the solution space. While this naturally leads to a standard MAP estimation framework, performance is compromised by unknown trade-off parameter settings, optimization heuristics, and convergence issues stemming from non-convexity and/or poor prior selections. To mitigate some of these problems, a number of authors have recently proposed substituting a variational…
Re-thinking Richardson-Lucy without Iteration Cutoffs: Physically Motivated Bayesian Deconvolution
Center for Biological Physics, Arizona State University（亚利桑那州立大学生物物理中心）；Department of Physics, Arizona State University（亚利桑那州立大学物理系）；School of Molecular Sciences, Arizona State University（亚利桑那州立大学分子科学学院）
Technical University of Munich（慕尼黑工业大学）；University of Siegen（锡根大学）
While variational methods have been among the most powerful tools for solving linear inverse problems in imaging, deep (convolutional) neural networks have recently taken the lead in many challenging benchmarks. A remaining drawback of deep learning approaches is their requirement for an expensive retraining whenever the specific problem, the noise level, noise type, or desired measure of fidelity changes. On the contrary, variational methods have a plug-and-play nature as they usually consist of separate data fidelity and regularization terms. In this paper we study the possibility of replaci…
Variational Positive-incentive Noise: How Noise Benefits Models
Institute of Artificial Intelligence (TeleAI), China Telecom（人工智能研究院（TeleAI），中国电信）；The University of Hong Kong（香港大学）；School of Artificial Intelligence, OPtics and ElectroNics (iOPEN), Northwestern Polytechnical University（人工智能学院（iOPEN），西北工业大学）
Deep neural network approaches to inverse imaging problems have produced impressive results in the last few years. In this paper, we consider the use of generative models in a variational regularisation approach to inverse problems. The considered regularisers penalise images that are far from the range of a generative model that has learned to produce images similar to a training dataset. We name this family \textit{generative regularisers}. The success of generative regularisers depends on the quality of the generative model and so we propose a set of desired criteria to assess generative mo…
