用于癌症治疗的倍频纳米晶体
Frequency Doubling Nanocrystals for Cancer Theranostics
摘要：
提出了一种基于非中心对称纳米粒子产生二次谐波的非线性光学过程的新型生物光子学方法，并在恶性人类细胞系上进行了演示。所提出的方法允许在不存在光敏分子的情况下直接与DNA相互作用，以通过简单地调谐激发激光波长来实现两种操作模式之间的独立成像和治疗模式切换，并且避免由任何自然或人工光源自发激活的任何风险。
英文摘要：
A novel bio-photonics approach based on the nonlinear optical process of second harmonic generation by non-centrosymmetric nanoparticles is presented and demonstrated on malignant human cell lines. The proposed method allows to directly interact with DNA in absence of photosensitizing molecules, to enable independent imaging and therapeutic modalities switching between the two modes of operation by simply tuning the excitation laser wavelength, and to avoid any risk of spontaneous activation by any natural or artificial light source.
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