T7 DNA的静电图。T7 RNA聚合酶特异性启动子功能和静电特性的比较分析
Electrostatic map of T7 DNA. Comparative analysis of functional and electrostatic properties of T7 RNA polymerase specific promoters
摘要：
整个T7噬菌体基因组含有39937个碱基对（数据库NCBI RefSeq N1001604）。本文采用Sorokin A.A.的计算机程序，通过库仑法计算了双螺旋T7 DNA周围的静电势分布。分析了T7噬菌体特异性RNA聚合酶识别的17个启动子的静电分布。结果表明，所有T7 RNA聚合酶特异性启动子的静电分布可以通过对每个启动子类别具有特异性的独特基序来表征。不同类别的天然T7启动子的静电分布的比较分析表明，T7 RNA聚合酶可以区分它们，由于它们的静电特征。
英文摘要：
The entire T7 bacteriophage genome contains 39937 base pairs (Database NCBI RefSeq N1001604). Here, electrostatic potential distribution around double helical T7 DNA was calculated by Coulomb method using the computer program of Sorokin A.A. Electrostatic profiles of 17 promoters recognized by T7 phage specific RNA polymerase were analyzed. It was shown that electrostatic profiles of all T7 RNA polymerase specific promoters can be characterized by distinctive motifs which are specific for each promoter class. Comparative analysis of electrostatic profiles of native T7 promoters of different classes demonstrates that T7 RNA polymerase can differentiate them due to their electrostatic features.
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