用于剂量计算和累积的质量守恒四维XCAT体模
A Mass-Conserving 4D XCAT Phantom for Dose Calculation and Accumulation
摘要：
XCAT体模是一种逼真的4D数字躯干体模，广泛用于成像和治疗研究。然而，肺质量在体模的呼吸阶段之间不守恒，使得详细的剂量测定模拟和剂量累积不符合物理学。开发了一个框架，通过在XCAT肺中实施局部质量守恒来纠正这个问题。进行剂量计算，以评估忽略质量守恒的影响，并证明应用体模计算呼吸不规则患者的累积输送剂量。蒙特卡罗方法用于模拟常规和SBRT治疗输送。通过使用质量守恒定性地改变了肺剂量的空间分布;然而，相应的DVH没有显著改变。输送剂量与基于4DCT的预测的比较显示了相似的肺度量结果，但是在一些空间区域中可以看到10%的剂量差异。使用此工具模拟患者治疗，可显示计划剂量与计算的完整治疗输送剂量之间的差异。该软件可从作者处免费获得。
英文摘要：
The XCAT phantom is a realistic 4D digital torso phantom that is widely used in imaging and therapy research. However, lung mass is not conserved between respiratory phases of the phantom, making detailed dosimetric simulations and dose accumulation unphysical. A framework is developed to correct this issue by enforcing local mass conservation in the XCAT lung. Dose calculations are performed to assess the implications of neglecting mass conservation, and to demonstrate an application of the phantom to calculate the accumulated delivered dose in an irregularly breathing patient. Monte Carlo methods are used to simulate conventional and SBRT treatment delivery. The spatial distribution of the lung dose was qualitatively changed by the use of mass conservation; however the corresponding DVH did not change significantly. Comparison of the delivered dose with 4DCT-based predictions shows similar lung metric results, however dose differences of 10% can be seen in some spatial regions. Using this tool to simulate patient treatments reveals differences between the planned dose and the calculated delivered dose for the full treatment. The software is freely available from the authors.
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