低剂量吸入氡子体细胞命中率与转化概率的非线性关系
Non-linear relationship of cell hit and transformation probabilities in low dose of inhaled radon progenies
摘要：
在低暴露水平下模拟吸入氡后代在敏感支气管上皮细胞核中发射的α粒子的细胞命中概率，以获得用于排斥或支持线性非阈值（LNT）假设的有用数据。在这项研究中，局部分布的沉积吸入氡子体在气道分叉模型计算暴露条件下，这是家庭和铀矿的特点。然后，在支气管气道分叉处的最大局部沉积增强因子，表示为局部沉积密度与平均沉积密度的比率，被确定为表征沉积的不均匀性，并阐明其对所产生的命中概率的影响。获得的结果表明，在中央气道隆突区域附近，即使在低平均剂量下，多次击中的概率也相当高。假设放射性均匀分布，实际上没有多次命中，命中概率作为剂量的函数在低剂量范围内呈现线性形状。结果是完全相反的情况下，热点显示的实际沉积计算，其中几乎所有的细胞接收多个命中和命中概率作为剂量的函数是非线性的平均剂量范围为10-100 mGy。
英文摘要：
Cellular hit probabilities of alpha particles emitted by inhaled radon progenies in sensitive bronchial epithelial cell nuclei were simulated at low exposure levels to obtain useful data for the rejection or in support of the linear-non-threshold (LNT) hypothesis. In this study, local distributions of deposited inhaled radon progenies in airway bifurcation models were computed at exposure conditions, which are characteristic of homes and uranium mines. Then, maximum local deposition enhancement factors at bronchial airway bifurcations, expressed as the ratio of local to average deposition densities, were determined to characterize the inhomogeneity of deposition and to elucidate their effect on resulting hit probabilities. The results obtained suggest that in the vicinity of the carinal regions of the central airways the probability of multiple hits can be quite high even at low average doses. Assuming a uniform distribution of activity there are practically no multiple hits and the hit probability as a function of dose exhibits a linear shape in the low dose range. The results are quite the opposite in the case of hot spots revealed by realistic deposition calculations, where practically all cells receive multiple hits and the hit probability as a function of dose is non-linear in the average dose range of 10-100 mGy.
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