表观遗传追踪：多细胞生物学模型
Epigenetic Tracking: a Model for Multicellular Biology
摘要：
表观遗传跟踪是生物细胞的数学模型，最初设想用于研究胚胎发育。计算机模拟证明了该模型生成复杂三维细胞结构的能力，以及再现生物典型复杂性的潜力。该模型最显著的特征是在体内存在均匀分布的干细胞，这些干细胞在发育过程中从非干细胞动态地和连续地产生并驻留在小生境中。胚胎干细胞协调早期发育事件，成体干细胞指导晚期发育和再生事件，衰老干细胞导致衰老，癌症干细胞负责癌症生长。表观遗传跟踪提供的概念支柱汇集了广泛的生物现象：出于这个原因，我们认为它可以被提议作为多细胞生物学的一般模型。尽管如此，或者可能是由于其理论起源，该模型使我们能够对生物学的不同领域进行预测，例如转座因子和与癌症相关的基因突变模式。本文包括一个总结的模型及其影响。
英文摘要：
Epigenetic Tracking is a mathematical model of biological cells, originally conceived to study embryonic development. Computer simulations proved the capacity of the model to generate complex 3-dimensional cellular structures, and the potential to reproduce the complexity typical of living beings. The most distinctive feature of this model is the presence in the body of a homogeneous distribution of stem cells, which are dinamically and continuously created during development from non-stem cells and reside in niches. Embryonic stem cells orchestrate early developmental events, adult stem cells direct late developmental and regeneration events, ageing stem cells cause ageing and cancer stem cells are responsible for cancer growth. The conceptual backbone provided by Epigenetic Tracking brings together a wide range of biological phenomena: for this reason, we think it can be proposed as a general model for multicellular biology. Despite, or perhaps due to its theoretical origin, the model allowed us to make predictions relevant to very diverse fields of biology, such as transposable elements, and cancer-related patterns of gene mutations. This paper contains a summary of the model and its implications.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
