利什曼病的合成生物学：构建遗传电路的设计、模拟和验证
Synthetic Biology in Leishmaniasis: Design,simulation and validation of constructed Genetic circuit
摘要：
构建电路并研究它们在细胞中的行为是系统和合成生物学的主要目标。合成生物学使系统研究的细胞状态的精确控制，新的部分，控制策略的发现，和鲁棒的合成系统的设计的相互作用。据我们所知，目前还没有关于原生动物寄生虫合成回路构建的文献报道。本文介绍了靶向酶肌醇磷酸神经酰胺合酶属于原生动物寄生虫利什曼原虫的遗传电路的构建。为了探索所设计的电路的动态特性，进行了仿真，然后通过定性和定量的方法进行电路验证。肌醇磷酸神经酰胺合酶的遗传电路设计显示出响应性，振荡和振荡行为，以及内在的鲁棒性。
英文摘要：
Building circuits and studying their behavior in cells is a major goal of systems and synthetic biology. Synthetic biology enables the precise control of cellular states for systems studies, the discovery of novel parts, control strategies, and interactions for the design of robust synthetic systems. To the best of our knowledge,there are no literature reports for the synthetic circuit construction for protozoan parasites. This paper describes the construction of genetic circuit for the targeted enzyme inositol phosphorylceramide synthase belonging to the protozoan parasite Leishmania. To explore the dynamic nature of the circuit designed, simulation was done followed by circuit validation by qualitative and quantitative approaches. The genetic circuit designed for inositol phosphorylceramide synthase shows responsiveness, oscillatory and bistable behavior, together with intrinsic robustness.
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