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arXiv 1303.6596cond-mat.stat-mechphysics.bio-ph
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非平衡稳态之间转换的最优控制

Optimal control of transitions between nonequilibrium steady states

Patrick R. Zulkowski, David A. Sivak, Michael R. DeWeese

摘要:

生物系统从根本上说是不平衡的,以保持有组织的结构和过程。许多变化的细胞条件可以表示为非平衡稳态之间的转换,并且生物体对优化这种转换感兴趣。使用波多野佐佐的Y值,我们扩展了最近开发的几何框架,确定最佳的协议,使它可以应用到系统驱动的非平衡稳态。我们计算和数值验证的最佳方案的胶体粒子拖动通过解决方案的平移光阱与两个可控参数。我们提供实验预测,特别是最佳协议的成本显着低于天真的。类似于这些的最佳方案可能最终指向生物能量转换系统的设计原则,并指导人工分子机器的设计。

英文摘要:

Biological systems fundamentally exist out of equilibrium in order to preserve organized structures and processes. Many changing cellular conditions can be represented as transitions between nonequilibrium steady states, and organisms have an interest in optimizing such transitions. Using the Hatano-Sasa Y-value, we extend a recently developed geometrical framework for determining optimal protocols so that it can be applied to systems driven from nonequilibrium steady states. We calculate and numerically verify optimal protocols for a colloidal particle dragged through solution by a translating optical trap with two controllable parameters. We offer experimental predictions, specifically that optimal protocols are significantly less costly than naive ones. Optimal protocols similar to these may ultimately point to design principles for biological energy transduction systems and guide the design of artificial molecular machines.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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