离体人体皮肤各向异性力学特性的表征
Characterising the Anisotropic Mechanical Properties of Excised Human Skin
摘要：
皮肤的机械性能对于包括外科手术、皮肤病学、冲击生物力学和法医学的许多应用是重要的。在这项研究中，我们已经调查了位置和方向上的变形特性的56个样本的离体人体皮肤的影响。单轴拉伸试验在0.012 s $^{-1}$的应变速率下从背部对皮肤进行。数字图像相关用于2D应变测量，并对真皮进行组织学检查。平均极限拉伸强度（UTS）为21.6 $\pm$ 8.4 MPa，平均失效应变为54 $\pm$ 17%，平均初始斜率为1.18 $\pm$ 0.88 MPa，平均弹性模量为83.3 $\pm$ 34.9 MPa，平均应变能为3.6 $\pm$ 1.6 MJ/m $^3$。多变量方差分析表明，皮肤的这些机械性能取决于Langer线的方向（P $<$ 0.0001-P=0.046）。还发现样本在背部的位置对UTS（P =0.0002）、弹性模量（P=0.001）和应变能（P=0.0052）有显著影响。组织学研究得出结论，朗格线的取向与真皮中胶原纤维的优选取向之间存在明确的相关性（P $<$ 0.001）。在这项研究中获得的数据将提供必要的信息，为那些希望使用结构本构模型的皮肤建模。
英文摘要：
The mechanical properties of skin are important for a number of applications including surgery, dermatology, impact biomechanics and forensic science. In this study we have investigated the influence of location and orientation on the deformation characteristics of 56 samples of excised human skin. Uniaxial tensile tests were carried out at a strain rate of 0.012s$^{-1}$ on skin from the back. Digital Image Correlation was used for 2D strain measurement and a histological examination of the dermis was also performed. The mean ultimate tensile strength (UTS) was 21.6$\pm$8.4MPa, the mean failure strain 54$\pm$17%, the mean initial slope 1.18$\pm$0.88MPa, the mean elastic modulus 83.3$\pm$34.9MPa and the mean strain energy was 3.6$\pm$1.6MJ/m$^3$. A multivariate analysis of variance has shown that these mechanical properties of skin are dependent upon the orientation of Langer lines (P$<$0.0001-P=0.046). The location of specimens on the back was also found to have a significant effect on the UTS (P =0.0002), the elastic modulus (P=0.001) and the strain energy (P=0.0052). The histological investigation concluded that there is a definite correlation between the orientation of Langer Lines and the preferred orientation of collagen fibres in the dermis (P$<$0.001). The data obtained in this study will provide essential information for those wishing to model the skin using a structural constitutive model.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
