直接在羟基磷灰石上产生静电微区：用开尔文力探针和蛋白质探测
Directly created electrostatic micro-domains on hydroxyapatite: probing with a Kelvin Force probe and a protein
摘要：
利用扫描电子显微镜的微探针--中能聚焦电子束，在羟基磷灰石（HAp）薄膜上直接形成表面修饰电位（SP）微区。这些图案的SP分布已研究了亚微米尺度上的开尔文探针力显微镜方法以及溶菌酶吸附。由于溶菌酶在生理pH下带正电荷，因此它允许我们跟踪SP模式的带正电荷和带负电荷的区域。吸附的蛋白质的分布在域是在良好的协议与观察到的SP模式。
英文摘要：
Micro-domains of modified surface potential (SP) were created on hydroxyapatite (HAp) films by direct patterning by midenergy focused electron beam, typically available as a microprobe of Scanning Electron Microscopes. The SP distribution of these patterns has been studied on sub-micrometer scale by the Kelvin Probe Force Microscopy method as well as lysozyme adsorption. Since the lysozyme is positively charged at physiological pH, it allows us to track positively and negatively charged areas of the SP patterns. Distribution of the adsorbed proteins over the domains was in good agreement with the observed SP patterns.
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