闪烁分子追踪
Blinking Molecule Tracking
摘要：
我们讨论了一种用于跟踪单个分子的方法，该方法全局优化了分子位置之间的连接的可能性，即使对于高斑点密度和闪烁的分子，也具有高可靠性。我们的方法与成本函数，可以自由选择，结合成本的空间和时间点之间的距离，可以考虑定位分子的可靠性。为此，我们描述了一个自上而下的多面体的方法来跟踪许多单个分子的问题。这立即产生使用标准线性规划求解器的有效实现。我们的方法可以应用于2D和3D跟踪。
英文摘要：
We discuss a method for tracking individual molecules which globally optimizes the likelihood of the connections between molecule positions fast and with high reliability even for high spot densities and blinking molecules. Our method works with cost functions which can be freely chosen to combine costs for distances between spots in space and time and which can account for the reliability of positioning a molecule. To this end, we describe a top-down polyhedral approach to the problem of tracking many individual molecules. This immediately yields an effective implementation using standard linear programming solvers. Our method can be applied to 2D and 3D tracking.
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