生命的物理学：一次一个分子
The Physics of Life: one molecule at a time
摘要：
受人尊敬的物理学家欧文·薛定谔（Erwin Schroedinger）的名字与最臭名昭著的量子力学方程联系在一起，他也写了一篇题为“生命是什么？”的短文。’，问道：“在一个生物体的空间边界内发生的空间和时间中的事件如何能用物理学和化学来解释呢？“在这项开创性工作之后的60多年里，我们在分子尺度上对生物学的理解有了巨大的发展，物理学通过开发和应用新的物理科学技术，生物物理分析和严谨的智力洞察力，在解决许多核心问题方面发挥了关键作用。早期的单分子生物物理学研究主要集中在分子马达和生物聚合物上，在很大程度上脱离了真实的生理背景。新一代的单分子生物科学研究有更大的范围，涉及强大的方法来理解最基本的生物过程的分子水平的细节，在更现实的，技术上具有挑战性的，生理环境，新兴的“单分子细胞生物制药学”的新领域。在这里，我概述了这个新领域是如何发展的，讨论了当前研究的关键活跃领域，并推测了这一切在不久的将来可能会导致什么。
英文摘要：
The esteemed physicist Erwin Schroedinger, whose name is associated with the most notorious equation of quantum mechanics, also wrote a brief essay entitled 'What is Life?', asking: 'How can the events in space and time which take place within the spatial boundary of a living organism be accounted for by physics and chemistry?' The 60+ years following this seminal work have seen enormous developments in our understanding of biology on the molecular scale, physics playing a key role in solving many central problems through the development and application of new physical science techniques, biophysical analysis and rigorous intellectual insight. The early days of single molecule biophysics research was centred around molecular motors and biopolymers, largely divorced from a real physiological context. The new generation of single molecule bioscience investigations has much greater scope, involving robust methods for understanding molecular level details of the most fundamental biological processes in far more realistic, and technically challenging, physiological contexts, emerging into a new field of 'single molecule cellular biophysics'. Here, I outline how this new field has evolved, discuss the key active areas of current research, and speculate on where this may all lead in the near future.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
