拟南芥基因体表观遗传DNA甲基化的数学框架
Mathematical framework of epigenetic DNA methylation in gene body Arabidopsis
摘要：
为了解释拟南芥基因体甲基化模式的建立、维持和稳定性，我们提出了一个理论框架，以理解DNA复制过程中胞嘧啶残基的甲基化和非甲基化状态是如何维持和传递的。在统计力学中路由，本文构建的框架用于探索表观遗传遗传的最小模型，并确定在DNA复制轮次内胞嘧啶的甲基化/未甲基化状态的稳定性的必要条件。这些模型足够灵活，可以添加新的生物学概念和信息。
英文摘要：
In aiming to explain the establishment, maintenance and stability of methylation pattern in gene body of Arabidopsis we propose here a theoretical framework for understanding how the methylated and unmethylated states of cytosine residues are maintained and transmitted during DNA replication. Routed in statistical mechanics, the framework built herein is used to explore minimal models of epigenetic inheritance and identify the necessary conditions for stability of methylated/unmethylated states of cytosine over rounds of DNA replication. The models are flexible enough to allow adding new biological concepts and information.
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