电流体动力学脉冲给药系统中液滴尺寸和形成时间的计算
Calculation of Droplet Size and Formation Time in Electrohydrodynamic Based Pulsatile Drug Delivery System
摘要：
电流体动力学（EHD）产生是生物MEMS中常用的方法，在脉冲药物释放系统中发挥了重要作用。本文设计了一种基于EHD的药物输送系统，该系统在1500 V的外加电压下，可在8.5 ms内产生2.83 nL的药物液滴，整个装置为2 × 2 × 3 mm^3。从理论上推导了EHD法产生的液滴大小和形成时间的表达式，同时考虑药物供应速率、液体性质、电极之间的间隙、喷嘴尺寸和带电液滴中和。本工作证明了基于EHD方法的液滴生成和输送系统的可重复性、稳定性和可控性。
英文摘要：
Electrohydrodynamic (EHD) generation, a commonly used method in BioMEMS, plays a significant role in the pulsed-release drug delivery system for a decade. In this paper, an EHD based drug delivery system is well designed, which can be used to generate a single drug droplet as small as 2.83 nL in 8.5 ms with a total device of 2x2x3 mm^3, and an external supplied voltage of 1500 V. Theoretically, we derive the expressions for the size and the formation time of a droplet generated by EHD method, while taking into account the drug supply rate, properties of liquid, gap between electrodes, nozzle size, and charged droplet neutralization. This work proves a repeatable, stable and controllable droplet generation and delivery system based on EHD method.
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