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arXiv 1206.6519stat.MLstat.COstat.ME
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一种检验多维交互作用的排列方法

A Permutation Approach to Testing Interactions in Many Dimensions

Noah Simon, Robert Tibshirani

摘要:

到目前为止,测试在高维度的相互作用一直是一项具有挑战性的任务。现有的方法通常存在对建模假设和严重渐近标称p值敏感的问题。为了帮助缓解这些问题,我们提出了一个基于置换的方法来测试边际相互作用的二进制响应。我们的方法搜索类别之间不同的成对相关性。在这篇文章中,我们将我们的方法在真实和模拟数据上与运行许多成对logistic模型的标准方法进行了比较。在模拟数据上,我们的方法以较低的错误发现率发现更显著的相互作用(特别是在存在主效应的情况下)。在真实的基因组数据上,虽然没有金标准,但我们的方法发现了明显的信号并讲述了一个可信的故事,而逻辑斯谛回归没有。在不太严格的假设下,我们也给出了渐近一致性结果.

英文摘要:

To date, testing interactions in high dimensions has been a challenging task. Existing methods often have issues with sensitivity to modeling assumptions and heavily asymptotic nominal p-values. To help alleviate these issues, we propose a permutation-based method for testing marginal interactions with a binary response. Our method searches for pairwise correlations which differ between classes. In this manuscript, we compare our method on real and simulated data to the standard approach of running many pairwise logistic models. On simulated data our method finds more significant interactions at a lower false discovery rate (especially in the presence of main effects). On real genomic data, although there is no gold standard, our method finds apparent signal and tells a believable story, while logistic regression does not. We also give asymptotic consistency results under not too restrictive assumptions.

机构、总结、中文摘要均由AI分析而来,可能存在错误,请以论文正文为准。

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