粘附性纳米组分诱导膜管形成的机理
Mechanism of membrane tube formation induced by adhesive nanocomponents
摘要：
我们报告的数值模拟大胶体颗粒驱动的膜tubes。使用蒙特卡罗模拟，我们研究了该过程如何取决于颗粒大小，浓度和结合强度，并提出准确的自由能计算，以整理出如何管形成比较与竞争的萌芽过程。我们发现，管的形成是粘附在表面上的颗粒的集体行为的结果，并且它发生的结合强度小于出芽所需的那些。我们还发现，在膜表面上形成的颗粒的长线性聚集体通过降低与该过程相关联的自由能垒而充当成核种子。
英文摘要：
We report numerical simulations of membrane tubulation driven by large colloidal particles. Using Monte Carlo simulations we study how the process depends on particle size, concentration and binding strength, and present accurate free energy calculations to sort out how tube formation compares with the competing budding process. We find that tube formation is a result of the collective behavior of the particles adhering on the surface, and it occurs for binding strengths that are smaller than those required for budding. We also find that long linear aggregates of particles forming on the membrane surface act as nucleation seeds for tubulation by lowering the free energy barrier associated to the process.
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