细胞内扩散对钾通道电流-电压曲线的影响
Effect of intracellular diffusion on current-voltage curves in potassium channels
摘要：
我们研究了细胞内离子扩散对透过细胞膜的离子电流的影响。穿过细胞膜的离子流由形成特定通道的特殊蛋白质介导。近年来，钾离子通道的结构得到了广泛的研究，并取得了显著的成果：现在可以非常精确地测量单个通道的真实电流。然而，尽管分子动力学和动力学模型提供了部分见解，但仍然缺乏对通道行为的完整理解。在本文中，我们证明，通过分析KcsA的电流-电压电流通过一个合适的晶格模型，细胞内扩散起着至关重要的作用，渗透现象。选择性过滤行为和细胞内侧的离子扩散之间的相互作用允许对电流-电压曲线的充分解释。
英文摘要：
We study the effect of intracellular ion diffusion on ionic currents permeating through the cell membrane. Ion flux across the cell membrane is mediated by special proteins forming specific channels. The structure of potassium channels have been widely studied in recent years with remarkable results: very precise measurements of the true current across a single channel are now available. Nevertheless, a complete understanding of the behavior of the channel is still lacking, though molecular dynamics and kinetic models have provided partial insights. In this paper we demonstrate, by analyzing the KcsA current-voltage currents via a suitable lattice model, that intracellular diffusion plays a crucial role in the permeation phenomenon. The interplay between the selectivity filter behavior and the ion diffusion in the intracellular side allows a full explanation of the current-voltage curves.
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