狭缝中线性和圆形DNA链的数值研究：度量和拓扑性质
Numerical study of linear and circular model DNA chains confined in a slit: metric and topological properties
摘要：
利用先进的蒙特卡罗模拟研究了纳米缝约束对模型DNA链的度规和拓扑性质的影响。我们考虑线性和环状链的轮廓长度在1.2- 4.8 $μ$ m的范围和狭缝宽度连续跨越50- 1250 nm的范围。由de Gennes的斑点模型预测的度量缩放被示出为线性和环状DNA保持到最强的限制水平。更值得注意的是，环状DNA分子的拓扑性质与三维限制相比有两个主要差异。首先，整体打结概率是非单调的增加限制，可以大大提高或抑制相比，散装的情况下，通过简单地改变狭缝宽度。其次，结人口由结，是远远简单的比三维约束。结果表明，纳米狭缝可用于纳米流体装置中，以产生具有简单拓扑结构（包括未结）的DNA环，或通过结类型分离DNA环的异质集合。
英文摘要：
Advanced Monte Carlo simulations are used to study the effect of nano-slit confinement on metric and topological properties of model DNA chains. We consider both linear and circularised chains with contour lengths in the 1.2--4.8 $μ$m range and slits widths spanning continuously the 50--1250nm range. The metric scaling predicted by de Gennes' blob model is shown to hold for both linear and circularised DNA up to the strongest levels of confinement. More notably, the topological properties of the circularised DNA molecules have two major differences compared to three-dimensional confinement. First, the overall knotting probability is non-monotonic for increasing confinement and can be largely enhanced or suppressed compared to the bulk case by simply varying the slit width. Secondly, the knot population consists of knots that are far simpler than for three-dimensional confinement. The results suggest that nano-slits could be used in nano-fluidic setups to produce DNA rings having simple topologies (including the unknot) or to separate heterogeneous ensembles of DNA rings by knot type.
机构、总结、中文摘要均由AI分析而来，可能存在错误，请以论文正文为准。
